Potential roles of tumor-derived exosomes in angiogenesis.
Potential roles of tumor-derived exosomes in angiogenesis.
复制标题
肿瘤来源的外泌体在血管生成中的潜在作用。
DOI：
10.1080/14728222.2018.1464141
复制
发表时间：
2018-05
影响因子：
5.8
通讯作者：
Whiteside TL
中科院分区：
文献类型：
--
作者：
Ludwig N;Whiteside TL
肿瘤源性外泌体（TEX）及其通过加速血管生成在肿瘤进展中的作用是当前极大的兴趣。更好地理解TEX-血管串扰的机制可能会改善当前癌症的诊断、预后和治疗。对于实体瘤，充足的血液供应对于其发展、生长和转移至关重要。TEX是一种病毒大小的囊泡，在体液中自由循环并在肿瘤微环境（TME）中积累，已被认为是血管生成的新贡献者。TEX作为肿瘤和各种正常细胞之间的通讯系统，负责这些细胞的功能重编程。TEX向参与血管生成的受体细胞递送的分子和遗传物质促进血管生成的诱导和进展。靶向抑制TEX促血管生成功能可能是控制肿瘤进展的新治疗方法。在癌症患者的体液中循环的TEX携带复杂的分子和遗传货物，并且负责内皮细胞和驻留在TME中的其他正常细胞的表型和功能重编程。
Tumor-derived exosomes (TEX) and their role in tumor progression by accelerating angiogenesis are of great current interest. A better understanding of the mechanisms underlying TEX-blood vessels cross-talk may lead to improvements in current diagnosis, prognosis and treatment of cancer. For solid tumors, an adequate blood supply is of critical importance for their development, growth and metastasis. TEX, virus-size vesicles which circulate freely throughout body fluids and accumulate in the tumor microenvironment (TME), have been recognized as a new contributor to angiogenesis. TEX serve as a communication system between the tumor and various normal cells and are responsible for functional reprogramming of these cells. The molecular and genetic cargos that TEX deliver to the recipient cells involved in angiogenesis promote its induction and progression. The targeted inhibition of TEX pro-angiogenic functions might be a novel therapeutic approach for control of tumor progression. TEX circulating in body fluids of cancer patients carry a complex molecular and genetic cargo and are responsible for phenotypic and functional reprogramming of endothelial cells and other normal cells residing in the TME.
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DOI：
10.1111/j.1749-6632.1982.tb25720.x
发表时间：
1982-01-01
影响因子：
5.2
作者：
FOLKMAN, J
通讯作者：
FOLKMAN, J
影响因子：
--
作者：
Gopal SK;Greening DW;Hanssen EG;Zhu HJ;Simpson RJ;Mathias RA
通讯作者：
Mathias RA
影响因子：
4.6
作者：
Greening DW;Ji H;Chen M;Robinson BW;Dick IM;Creaney J;Simpson RJ
通讯作者：
Simpson RJ
影响因子：
3.4
作者：
Choi, Dong-Sic;Park, Jung Ok;Gho, Yong Song
通讯作者：
Gho, Yong Song
影响因子：
11.2
作者：
Grange, Cristina;Tapparo, Marta;Camussi, Giovanni
通讯作者：
Camussi, Giovanni