Mutation analysis of CBP and PCAF reveals rare inactivating mutations in cancer cell lines but not In primary tumours
Mutation analysis of CBP and PCAF reveals rare inactivating mutations in cancer cell lines but not In primary tumours
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DOI：
10.1038/sj.bjc.6600554
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发表时间：
2002-11-04
影响因子：
8.8
通讯作者：
Caldas, C
中科院分区：
文献类型：
--
作者：
Özdag, H;Batley, SJ;Caldas, C
在这项研究中，我们筛选了组蛋白乙酰转移酶CBP和PCAF在人类上皮癌细胞系和原发性肿瘤中的突变。我们确定了两个CBP截短（均在细胞系中），七个PCAF错义变体和四个CBP内含子微缺失。这些数据表明，在人类上皮癌中，这两种基因通常都没有失活。(C)2002年英国癌症研究。
In this study we screened the histone acetyltransferases CBP and PCAF for mutations in human epithelial cancer cell lines and primary tumours. We identified two CBP truncations (both in cell lines), seven PCAF missense variants and four CBP intronic microdeletions. These data suggest that neither gene is commonly inactivated in human epithelial cancers. (C) 2002 Cancer Research UK.