Prevalence of Treponema pallidum DNA among blood donors with two different serologic tests profiles for syphilis in São Paulo, Brazil.
Prevalence of Treponema pallidum DNA among blood donors with two different serologic tests profiles for syphilis in São Paulo, Brazil.
复制标题
在巴西圣保罗进行两种不同梅毒血清学检测的献血者中梅毒螺旋体 DNA 的患病率。
DOI：
10.1111/vox.12111
复制
发表时间：
2014
期刊：
影响因子：
2.7
通讯作者：
Sabino,EC
中科院分区：
文献类型：
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作者：
Ferreira,SC;deAlmeida-Neto,C;Nishiya,AS;Di-Lorenzo-Oliveira,C;Ferreira,JE;Alencar,CS;Levi,JE;Salles,NA;Mendrone-Junior,A;Sabino,EC
用实时荧光定量聚合酶链式反应技术检测梅毒血清学阳性献血员标本中梅毒螺旋体DNA的存在。在VDRL>；8、EIA+和FTA-ABS+献血者中，2例(1.02%)检出梅毒螺旋体DNA，而在80例VDRL−、EIA+和FTA-ABS+献血者中未检出梅毒螺旋体。献血者VDRL−、EIA+和FTA-ABS+缺乏血液中可见的T.梅毒DNA，不同于梅毒传播。献血者VDRL>；8、EIA+和FTA-ABS+即使在抗体检测的同时也有梅毒感染的风险。梅毒的血清学筛查仍可能起到防止其输血传播的作用。
The presence ofTreponema pallidumDNA was assessed by real‐time PCR in samples of blood donors with reactive serologic tests for syphilis.Treponema pallidumDNA was detected in two (1·02%) of 197 samples of VDRL>8, EIA+ and FTA‐ABS+ donors, and in no sample from 80 VDRL−, EIA+ and FTA‐ABS+ donors. Donors VDRL−, EIA+ and FTA‐ABS+ lack demonstrableT. pallidumDNA in their blood and are unlike to transmit syphilis. Donors VDRL>8, EIA+ and FTA‐ABS+ carry the risk of syphilis infectivity even in concomitance to antibodies detection. Serologic screening for syphilis may still play a role to prevent its transfusion transmission.