A Practical Approach to Rickets
A Practical Approach to Rickets
复制标题
DOI：
10.1159/000223692
复制
发表时间：
2009-01-01
期刊：
影响因子：
--
通讯作者：
Allgrove, Jeremy
中科院分区：
文献类型：
--
作者：
Allgrove, Jeremy
佝偻病是一种生长骨骼正常矿化失败（骨软化）的疾病。虽然成人可能出现骨软化症，但不会出现佝偻病。它通常是由于缺乏矿物质供应引起的，这可能是由于钙缺乏（钙缺乏性佝偻病）或磷酸盐缺乏（磷缺乏性佝偻病）造成的，尽管此外，肾小管酸中毒也可能干扰矿化过程并引起佝偻病。本章仅讨论钙减少和远端肾小管疾病。佝偻病最常见的原因仍然是维生素 D 缺乏，这也是佝偻病以外的问题的原因。维生素 D 代谢或反应障碍也可能引起类似的问题。远端肾小管酸中毒可能是由多种与破骨细胞类似的代谢错误引起的。一种形式的 DRTA 也会导致一种骨硬化症。本章详细描述了这些情况并提出了合理的治疗方法。版权所有 (C) 2009 S. Karger AG，巴塞尔
Rickets is a condition in which there is failure of normal mineralisation (osteomalacia) of growing bone. Whilst osteomalacia may be present in adults, rickets cannot occur. It is generally caused by a lack of mineral supply which can either be as a result of deficiency of calcium (calciopaenic rickets) or of phosphate (phosphopaenic rickets) although, in addition, renal tubular acidosis may also interfere with the process of mineralisation and cause rickets. Only calciopaenic and distal renal tubular disorders will be discussed in this chapter. The commonest cause of rickets is still vitamin D deficiency which is also responsible for problems other than rickets. Disorders of vitamin D metabolism or responsiveness may also cause similar problems. Distal renal tubular acidosis may be caused by a variety of metabolic errors similar to those of osteoclasts. One form of DRTA also causes a form of osteopetrosis. This chapter describes these conditions in detail and sets out a logical approach to treatment. Copyright (C) 2009 S. Karger AG, Basel