Estrogen receptor α revised: Expression, structure, function, and stability
Estrogen receptor α revised: Expression, structure, function, and stability
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DOI：
10.1002/bies.202200148
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发表时间：
2022-10-03
期刊：
影响因子：
4
通讯作者：
Shimada, Midori
中科院分区：
文献类型：
--
作者：
Habara, Makoto;Shimada, Midori
雌激素受体α (ER α)是一种调节雌激素应答基因表达的配体依赖性转录因子。大约70%的乳腺癌患者是ER α阳性。雌激素刺激癌细胞增殖，促进肿瘤进展。内分泌治疗可抑制ER α信号通路，显著改善乳腺癌患者的预后。然而，新生或获得性内分泌治疗耐药性的发展仍然是乳腺癌治疗的障碍。因此，了解内质网α的调控机制对于克服治疗耐药性至关重要。本文主要从拷贝数变异、表观遗传调控、转录调控、稳定性以及翻译后修饰等方面对ER α表达的调控进行综述。
Estrogen receptor alpha (ER alpha) is a ligand-dependent transcription factor that regulates the expression of estrogen-responsive genes. Approximately 70% of patients with breast cancer are ER alpha positive. Estrogen stimulates cancer cell proliferation and contributes to tumor progression. Endocrine therapies, which suppress the ER alpha signaling pathway, significantly improve the prognosis of patients with breast cancer. However, the development of de novo or acquired endocrine therapy resistance remains a barrier to breast cancer treatment. Therefore, understanding the regulatory mechanisms of ER alpha is essential to overcome the resistance to treatment. This review focuses on the regulation of ER alpha expression, including copy number variation, epigenetic regulation, transcriptional regulation, and stability, as well as functions from the point of view post-translational modifications.