A randomised controlled trial of adjunctive yoga and adjunctive physical exercise training for cognitive dysfunction in schizophrenia.
A randomised controlled trial of adjunctive yoga and adjunctive physical exercise training for cognitive dysfunction in schizophrenia.
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DOI：
10.1017/neu.2016.42
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发表时间：
2017-04
影响因子：
3.8
通讯作者：
Deshpande SN
中科院分区：
文献类型：
--
作者：
Bhatia T;Mazumdar S;Wood J;He F;Gur RE;Gur RC;Nimgaonkar VL;Deshpande SN
瑜伽和体育锻炼已被用作精神分裂症（SZ）认知功能障碍的辅助干预措施，但缺乏对照比较。根据先前的试点研究，设计了一项单盲随机对照试验，以评估瑜伽训练或体育锻炼是否可以增强深圳的认知功能。同意的、临床稳定的成年门诊 SZ 患者 (n = 286) 完成基线评估，并随机接受照常治疗 (TAU)、TAU 监督瑜伽训练 (YT) 或 TAU 监督体育锻炼训练 (PE)。根据试点研究，主要结果指标是宾夕法尼亚大学计算机化神经认知电池中“注意力”认知领域的速度指数。使用混合模型和对比，使用意向治疗范式评估基线、21 天（训练结束）、训练后 3 个月和 6 个月的认知功能。在 6 个月的随访中，YT 组的注意力域速度指数比 PE 组有更大的改善（p < 0.036，效应大小 0.51）。在 6 个月的随访中，PE 组的“注意域准确性指数”显示出比单独使用 TAU 更大的改善（p < 0.025，效应大小 0.61）。对于其他几个认知领域，与单独使用 TAU 相比，使用 YT 或 PE 观察到显着改善（p < 0.05，效应大小 0.30-1.97）。 YT 和 PE 都在训练期结束后改善了注意力和其他认知领域，支持了我们之前报道的 YT 对注意力领域速度指数的有益影响。作为辅助手段，YT 或 PE 可以使 SZ 患者受益。
Yoga and physical exercise have been used as adjunctive intervention for cognitive dysfunction in schizophrenia (SZ), but controlled comparisons are lacking. A single-blind randomised controlled trial was designed to evaluate whether yoga training or physical exercise training enhance cognitive functions in SZ, based on a prior pilot study. Consenting, clinically stable, adult outpatients with SZ (n = 286) completed baseline assessments and were randomised to treatment as usual (TAU), supervised yoga training with TAU (YT) or supervised physical exercise training with TAU (PE). Based on the pilot study, the primary outcome measure was speed index for the cognitive domain of ‘attention’ in the Penn computerised neurocognitive battery. Using mixed models and contrasts, cognitive functions at baseline, 21 days (end of training), 3 and 6 months post-training were evaluated with intention-to-treat paradigm. Speed index of attention domain in the YT group showed greater improvement than PE at 6 months follow-up (p < 0.036, effect size 0.51). In the PE group, ‘accuracy index of attention domain showed greater improvement than TAU alone at 6-month follow-up (p < 0.025, effect size 0.61). For several other cognitive domains, significant improvements were observed with YT or PE compared with TAU alone (p < 0.05, effect sizes 0.30–1.97). Both YT and PE improved attention and additional cognitive domains well past the training period, supporting our prior reported beneficial effect of YT on speed index of attention domain. As adjuncts, YT or PE can benefit individuals with SZ.