TIS11 family proteins and their roles in posttranscriptional gene regulation.
TIS11 family proteins and their roles in posttranscriptional gene regulation.
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DOI：
10.1155/2009/634520
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发表时间：
2009
影响因子：
--
通讯作者：
Murphy JJ
中科院分区：
文献类型：
--
作者：
Baou M;Jewell A;Murphy JJ
在3‘非翻译区含腺嘌呤-尿苷丰富元件(Ares)的mRNAs基因表达的转录后调控是由许多不同的蛋白质介导的，这些蛋白质与这些元件相互作用，稳定或破坏它们的稳定。本综述涉及TPA诱导的可诱导序列11(TIS11)蛋白家族，这是一个小的蛋白质家族，似乎与含有ARE的mRNAs相互作用并促进其降解。在过去的十年里，这个蛋白质家族得到了广泛的研究。研究的重点是确定它们的生化功能，确定它们的靶mRNAs，并确定它们在细胞功能和疾病中的作用。
Posttranscriptional regulation of gene expression of mRNAs containing adenine-uridine rich elements (AREs) in their 3′ untranslated regions is mediated by a number of different proteins that interact with these elements to either stabilise or destabilise them. The present review concerns the TPA-inducible sequence 11 (TIS11) protein family, a small family of proteins, that appears to interact with ARE-containing mRNAs and promote their degradation. This family of proteins has been extensively studied in the past decade. Studies have focussed on determining their biochemical functions, identifying their target mRNAs, and determining their roles in cell functions and diseases.
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