The mitochondrial permeability transition pore and cancer: molecular mechanisms involved in cell death.
The mitochondrial permeability transition pore and cancer: molecular mechanisms involved in cell death.
复制标题
DOI：
10.3389/fonc.2014.00302
复制
发表时间：
2014
影响因子：
4.7
通讯作者：
Pinton P
中科院分区：
文献类型：
--
作者：
Bonora M;Pinton P
线粒体通透性转变(MPT)自20世纪70年代被发现以来，一直被认为是细胞死亡的战略调节因子。大量的研究工作集中在阐明MPT的分子组成上，因为这一知识可能有助于更好地理解和治疗从神经退行性疾病和心脏疾病到癌症的各种病理。在癌症方面，一些研究揭示了线粒体通透性转换孔(MPTP)活性的变化，并确定了其调节机制；这些研究还表明，MPTP活性的抑制，而不是其失活，通常发生在实体肿瘤中。本文主要介绍了MPTP在肿瘤中调控的最新研究进展，并着重介绍了MPTP在阻止细胞死亡机制中的作用。
Since its discovery in the 1970s, the mitochondrial permeability transition (MPT) has been proposed to be a strategic regulator of cell death. Intense research efforts have focused on elucidating the molecular components of the MPT because this knowledge may help to better understand and treat various pathologies ranging from neurodegenerative and cardiac diseases to cancer. In the case of cancer, several studies have revealed alterations in the activity of the mitochondrial permeability transition pore (mPTP) and have determined its regulatory mechanism; these studies have also suggested that suppression of the activity of the mPTP, rather than its inactivation, commonly occurs in solid neoplasms. This review focuses on the most recent advances in understanding mPTP regulation in cancer and highlights the ability of the mPTP to impede the mechanisms of cell death.