Concise and Versatile Synthesis of Sulfoquinovosyl Acyl Glycerol Derivatives for Biological Applications.
Concise and Versatile Synthesis of Sulfoquinovosyl Acyl Glycerol Derivatives for Biological Applications.
复制标题
用于生物应用的磺基喹诺酰基酰基甘油衍生物的简洁、多功能合成。
DOI：
10.1248/cpb.c17-00135
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发表时间：
2017
影响因子：
1.7
通讯作者：
S. Aoki
中科院分区：
文献类型：
--
作者：
Tomohiro Tanaka;Y. Sawamoto;S. Aoki
磺基喹诺酮酰基丙二醇(SQAP)是一种磺基喹诺酮酰甘油(SQAG)的化学修饰类似物，存在于海藻中，具有多种生物活性，包括在肿瘤细胞中的蓄积和抑制肿瘤细胞的生长。我们在这里报道了一种新的简明和通用的合成SQAP本身及其含碘芳基和硼簇合物的衍生物。该方法可用于设计和合成用于诊断和治疗癌症及相关疾病的SQAG/SQAP衍生物。
Sulfoquinovosyl acylpropanediol (SQAP), a chemically modified analogue of sulfoquinovosyl acylglycerol (SQAG) that occurs in sea algae, has been reported to show a variety of biological activities, including accumulation in tumor cells and the inhibition of tumor cell growth. We report herein on a new concise and versatile synthesis of SQAP itself and derivatives bearing iodoaryl groups and boronclusters. This method should be useful for the design and synthesis of SQAG/SQAP derivatives for diagnosis and the treatment of cancer and related diseases.