Moving targets: Mechanisms regulating siRNA production and DNA methylation during plant development.
Moving targets: Mechanisms regulating siRNA production and DNA methylation during plant development.
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DOI：
10.1016/j.pbi.2023.102435
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发表时间：
2023-08
影响因子：
9.5
通讯作者：
Laura M. Martins;Julie A. Law
中科院分区：
文献类型：
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作者：
Laura M. Martins;Julie A. Law
DNA甲基化是一种保守的修饰，必须在发育过程中精确调节，以促进其在沉默转座元件和调节基因表达中的作用。在植物中，DNA甲基化变化在繁殖过程中被广泛记录，在许多情况下，潜在的机制被很好地理解。在体细胞组织中，甲基化模式的多样性直到最近才出现，但它们通常与rna定向DNA甲基化（RdDM）途径相关。在这里，我们讨论了我们对RdDM蛋白的位点特异性靶向和组织特异性表达如何调节甲基化模式的理解进展，甲基化靶向不完全同源位点如何扩大RdDM的范围，以及RdDM因子的自然变异如何影响DNA甲基化模式。
DNA methylation is a conserved modification that must be precisely regulated during development to facilitate its roles in silencing transposable elements and regulating gene expression. In plants, DNA methylation changes during reproduction are widely documented and, in many cases, the underlying mechanisms are well understood. In somatic tissues, the diversity of methylation patterns are only recently emerging but they are often associated with the RNA-directed DNA methylation (RdDM) pathway. Here, we discuss advances in our understanding of how the locus-specific targeting and tissue-specific expression of RdDM proteins regulate methylation patterns, how the targeting of methylation at loci with imperfect homology expands the purview of RdDM, and how natural variation within RdDM factors impacts DNA methylation patterns.