Chemotherapy is associated with increased survival from colorectal signet ring cell carcinoma with distant metastasis: A Surveillance, Epidemiology, and End Results database analysis
Chemotherapy is associated with increased survival from colorectal signet ring cell carcinoma with distant metastasis: A Surveillance, Epidemiology, and End Results database analysis
复制标题
化疗与远处转移的结直肠印戒细胞癌生存率增加相关：监测、流行病学和最终结果数据库分析
DOI：
10.1002/cam4.2054
复制
发表时间：
2019-04-01
期刊：
影响因子：
4
通讯作者：
Chu, Xiaoyuan
中科院分区：
文献类型：
--
作者：
Shi, Tao;Huang, Mengxi;Chu, Xiaoyuan
结直肠印戒细胞癌（colorectal signet ring cell carcinoma，SRCC）是结直肠腺癌的一种罕见的组织学亚型，与非SRCC结直肠癌（non-SRCC colorectal cancer，NOS）相比，具有较高的转移率。本研究的目的是分析结直肠SRCC与不同转移部位的预后因素，并评估各种治疗方法对转移性结直肠SRCC.MethodsPatients NOS和SRCC的影响来自2010-2014年期间的监测，流行病学和最终结果（SEER）数据库。χ（2）检验用于比较数据显著性。采用Kaplan-Meier和考克斯模型分析生存率的差异。倾向匹配分析被用来调整数值differentiation.ResultsAmong 173460例患者，1932（1.11%）例结直肠SRCC。在单因素分析中，年龄较大、男性和腹膜转移与较高的死亡风险相关。腹膜是小肾癌转移率最高的部位，也是预后最差的部位。在考克斯回归模型中，腹膜转移SRCC患者接受化疗有更好的生存率比患者接受surgical.ConclusionsOur研究分析了独特的转移模式，结直肠SRCC向不同的网站，发现相比，手术，化疗与结直肠SRCC患者有远处转移，这为今后SRCC患者的治疗提供了见解。
BackgroundColorectal signet ring cell carcinoma (SRCC) is a rare histological subtype of colorectal adenocarcinoma with high metastatic frequency compared to non-SRCC colorectal cancer (NOS). The aim of this study was to analyze prognostic factors of colorectal SRCC with different metastatic sites and evaluate impacts of various therapies for metastatic colorectal SRCC.MethodsPatients with NOS and SRCC were from the Surveillance, Epidemiology, and End Results (SEER) database during 2010-2014. chi(2) tests were used to compare data significance. Kaplan-Meier and COX models were used to analyze the differences in the survival. Propensity-matched analyses were used to adjust numerical differences.ResultsAmong the 173460 patients, 1932 (1.11%) patients had colorectal SRCC. In univariate analysis, older age, male sex, and peritoneum metastasis were associated with higher mortality risk. The peritoneum was both the site with the highest metastatic frequency and the site with the worst prognosis in SRCC. In the COX regression model, peritoneum-metastatic SRCC patients receiving chemotherapy had better survival than patients treated with surgery.ConclusionsOur study analyzed the unique metastatic pattern of colorectal SRCC toward different sites and found that compared to surgery, chemotherapy was associated with better survival for colorectal SRCC patients with distant metastasis, which provided insights for future SRCC patient treatment.