Age-related morphology trends of cortical sulci
Age-related morphology trends of cortical sulci
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DOI：
10.1002/hbm.20198
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发表时间：
2005-11-01
影响因子：
4.8
通讯作者：
Fox, PT
中科院分区：
文献类型：
--
作者：
Kochunov, P;Mangin, JF;Fox, PT
研究了正常成人皮层主沟宽度和深度的年龄变化趋势。对90名年龄在20 ~ 82岁的健康受试者（男性47名，女性43名）进行评价。通过高分辨率解剖MRI测量每个半球14个突出的沟结构的平均沟宽度和深度。平均沟宽以约0.7 mm/ 10年的速率增加，而平均沟深以约0.4 mm/ 10年的速率减少。颞上沟、侧支沟和扣带沟的年龄相关趋势受到性别的高度影响（P < 0.05），男性的沟宽年龄相关变化比女性更明显。与单峰皮质区相比，多峰皮质区沟结构的年龄相关变化更明显（P < 0.05）。
The age-related trends of the width and the depth of major cortical sulci were studied in normal adults. Ninety healthy subjects (47 males, 43 females) age 20-82 years were evaluated. Measurements of average sulcal width and depth in 14 prominent sulcal structures per hemisphere were performed with high-resolution anatomical MRI. The average sulcal width increased at a rate of about 0.7 mm/decade, while the average sulcal depth decreased at a rate of about 0.4 mm/decade. Sulcal age-related trends were found to be highly influenced by gender in the superior temporal, collateral, and cingulate sulci (P < 0.05), with males showing more pronounced age-related change in sulcal width than females. Sulcal structures located in multimodal cortical areas showed more profound age related changes than sulcal structures in unimodal cortical areas (P < 0.05).