Pancreatic polypeptide reduces appetite and food intake in humans
Pancreatic polypeptide reduces appetite and food intake in humans
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DOI：
10.1210/jc.2003-030630
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发表时间：
2003-08-01
影响因子：
5.8
通讯作者：
Bloom, SR
中科院分区：
文献类型：
--
作者：
Batterham, RL;Le Roux, CW;Bloom, SR
胰多肽（PP）是一种消化道激素，由胰腺在进食时释放。已证明血浆PP在与食物摄入增加相关的疾病中降低，在神经性厌食症中升高。此外，PP的外周给药已显示可减少啮齿动物的摄食量。这些发现表明，PP可能作为一种循环因子，调节食物摄入量。因此，我们在10名健康志愿者中进行了一项随机、双盲、安慰剂对照、交叉研究，研究了静脉输注PP（10 pmol/kg/min）对食欲和摄食量的影响。输注PP可降低食欲，并使自助午餐时的能量摄入减少12.8 ± 5.7%（P < 0.01）。更重要的是，食物摄入的抑制持续存在，使得通过食物日记评估的能量摄入在研究的晚上和第二天早上都显著降低。总体PP输注使累积24小时能量摄入减少25.3 ± 5.8%。总之，我们的数据表明PP会导致食欲和食物摄入量持续下降。
Pancreatic polypeptide (PP) is a gut hormone released from the pancreas in response to ingestion of food. Plasma PP has been shown to be reduced in conditions associated with increased food intake and elevated in anorexia nervosa. In addition peripheral administration of PP has been shown to decrease food intake in rodents. These findings suggest that PP may act as a circulating factor that regulates food intake. Therefore we investigated the effect of intravenous infusion of PP (10 pmol/kg/min) on appetite and food intake in a randomised double-blind placebo-controlled crossover study in ten healthy volunteers. Infusion of PP reduced appetite and decreased the energy intake at a buffet lunch two hours pot-infusion by 12.8 +/- 5.7% (P < 0.01). More importantly the inhibition of food intake was sustained, such that energy intake, as assessed by food diaries, was significantly reduced both the evening of the study and the following morning. Overall PP infusion reduced cumulative 24-hour energy intake by 25.3 +/- 5.8%. In conclusion our data demonstrates that PP causes a sustained decrease in both appetite and food intake.