Smoking cessation improves mortality in Japanese men: the Hisayama study
Smoking cessation improves mortality in Japanese men: the Hisayama study
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DOI：
10.1136/tc.2010.039362
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发表时间：
2012-07-01
期刊：
影响因子：
5.2
通讯作者：
Kiyohara, Yutaka
中科院分区：
文献类型：
--
作者：
Ikeda, Fumie;Ninomiya, Toshiharu;Kiyohara, Yutaka
背景虽然日本男性的吸烟率在发达国家中一直是最高的，关于戒烟是否能延长寿命的流行病学证据还没有很好的建立。方法根据吸烟状况对1083名年龄≥ 40岁的日本男性进行分类，并前瞻性随访18年结果目前吸烟是全因死亡的重要危险因素：目前每天吸烟1-19支、20-39支和≥ 40支的吸烟者的全因死亡的多变量校正HR为1.61（95% CI 1.16 - 2.22）、1.56（95% CI 1.08 - 2.23）和3.15（95% CI 1.59 - 6.24）。与从不吸烟者相比，以前吸烟者的全因死亡风险并没有增加。目前吸烟者的全因死亡的额外风险在戒烟后5年内趋于下降，最终达到几乎与从不吸烟者相当的水平。在戒烟≥ 10年的受试者中，癌症死亡风险降低了53%，而在戒烟≥ 10年的受试者中，心血管死亡风险降低了56%。
Background Although the smoking rate among Japanese men has been the highest in developed countries, the epidemiological evidence about whether smoking cessation can extend their lifespan is not well established.Methods A total of 1083 Japanese men aged >= 40 years were classified by their smoking status and followed up prospectively for 18 years (1988-2006).Results Current smoking was a significant risk factor for all-cause death: the multivariate-adjusted HRs of all-cause death for current smokers of 1-19, 20-39 and >= 40 cigarettes per day were 1.61 (95% CI 1.16 to 2.22), 1.56 (95% CI 1.08 to 2.23) and 3.15 (95% CI 1.59 to 6.24), respectively. Former smokers did not have an increased risk of all-cause death compared with never smokers. The excess risk of all-cause death for current smokers tended to decrease within 5 years after smoking cessation, eventually reaching a level almost equivalent to that of never smokers. The risk of cancer death decreased by 53% in subjects who had quit smoking for >= 10 years, while the risk of cardiovascular death decreased by 56% in subjects with the cessation period of