Correlates of co-occurring ADHD in drug-dependent subjects: Prevalence and features of substance dependence and psychiatric disorders
Correlates of co-occurring ADHD in drug-dependent subjects: Prevalence and features of substance dependence and psychiatric disorders
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DOI：
10.1016/j.addbeh.2008.05.003
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发表时间：
2008-09-01
影响因子：
4.4
通讯作者：
Kranzler, Henry R.
中科院分区：
文献类型：
--
作者：
Arias, Albert J.;Gelernter, Joel;Kranzler, Henry R.
我们检查了患有 SD 和注意力缺陷多动障碍 (ADHD) 的受试者中精神和物质依赖 (SD) 疾病的患病率和病程。方法：我们使用药物依赖和酒精中毒半结构化评估采访了 1761 名终生诊断为可卡因和/或阿片类药物依赖的成年人。使用广义估计方程分析的广义线性回归来检查 ADHD 的终生诊断与临床病程指标之间的关联，并确定 ADHD 的独特相关性。 结果：SD 样本中的终生 ADHD 患病率为 5.22%（相对于没有 SD 的个体组中的 0.85%）。 ADHD 与首次使用药物的年龄较早、SD 和精神科诊断较多、自杀未遂的可能性较大以及住院次数较多有关。在控制品行障碍后，ADHD 对首次药物使用年龄和 SD 诊断数量有独特的影响。结论：在可卡因或阿片类药物依赖的受试者中，ADHD 与更高的 SD 和精神合并症以及更严重的病程相关。 (C) 2008 Elsevier Ltd. 保留所有权利。
We examined the prevalence and course of psychiatric and substance dependence (SD) disorders in subjects with SD and attention deficit hyperactivity disorder (ADHD).Method: We interviewed 1761 adults with a lifetime diagnosis of cocaine and/or opioid dependence using the Semi-Structured Assessment for Drug Dependence and Alcoholism. Generalized linear regression with generalized estimating equation analysis was used to examine the associations between a lifetime diagnosis of ADHD and indicators of clinical course, and to identify unique correlates of ADHD.Results: Lifetime ADHD prevalence in the SD sample was 5.22% (vs. 0.85% in a group of individuals without SD). ADHD was associated with an earlier age of first substance use, more SD and psychiatric diagnoses, a greater likelihood of attempted suicide, and more hospitalizations. After controlling for conduct disorder, there were unique effects of ADHD on age of first substance use and number of SD diagnoses.Conclusion: In subjects with cocaine or opioid dependence, ADHD is associated with greater SD and psychiatric comorbidity and a more severe course of illness. (C) 2008 Elsevier Ltd. All rights reserved.