DEMENTIA - AGE-DEPENDENT INCIDENCE, PREVALENCE, AND MORTALITY IN THE OLD OLD
DEMENTIA - AGE-DEPENDENT INCIDENCE, PREVALENCE, AND MORTALITY IN THE OLD OLD
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DOI：
10.1001/archinte.151.5.989
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发表时间：
1991-05-01
影响因子：
--
通讯作者：
FRISHMAN, W
中科院分区：
文献类型：
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作者：
ARONSON, MK;OOI, WL;FRISHMAN, W
据报道，年龄是痴呆症的一个重要风险因素。支持性数据主要来自流行病学研究，这些研究的标准和样本组成各不相同，无法进行直接比较，特别是在85岁及以上的人群中。关于痴呆率的数据是基于布朗克斯（纽约）老龄化研究中的85个病例，这是一项对488名最初无痴呆的老年人（入组时平均年龄79岁）的前瞻性研究。总体而言，在8年的随访中，全因痴呆的发病率为每年3.4 / 100（43%为阿尔茨海默病，30%为阿尔茨海默病和血管性痴呆混合，27%为其他）。发病率显著上升，与性别无关，因为受试者随访了三个年龄区间——75至79岁（每年1.3/100），80至84岁（每年3.5）和85岁及以上（每年6.0）。痴呆的年龄相关患病率分别为3.7%、12.2%和23.9%，总体患病率为22.8%。此外，与痴呆症相关的死亡率高出三倍。总之，尽管痴呆症患者的预期寿命缩短，但在85岁及以上的人群中，痴呆症是一种非常普遍的疾病。公共政策的关注是有必要的，因为这一群体是人口增长最快的群体。
Age has been reported as a strong risk factor for dementia. Supporting data have been derived mainly from prevalence studies, which had varied criteria and sample compositions that precluded direct comparisons, especially among those aged 85 years and older. Data regarding rates of dementia are presented based on 85 incident cases in the Bronx (NY) Aging Study, a prospective study of 488 initially nondemented, old old persons (mean age on entry, 79 years). Overall, the incidence rate over 8 years of follow-up for all-cause dementia was 3.4 per 100 per year (43% Alzheimer's disease, 30% mixed Alzheimer's and vascular, and 27% other). Incidence rose significantly, irrespective of gender, as subjects were followed up through three age intervals - ages 75 to 79 years (1.3/100 per year), 80 to 84 years (3.5), and 85 years and older (6.0). The comparable age-associated prevalence rates of dementia were 3.7%, 12.2%, and 23.9%, respectively, with an overall period prevalence of 22.8%. Additionally, there was a threefold greater mortality associated with dementia. In conclusion, despite the shortened life expectancy of demented persons, dementia is a highly prevalent condition among those aged 85 years and older. Public policy attention is warranted, since this group is the fastest growing population subgroup.