Circulating CTRP9 levels are increased in patients with newly diagnosed type 2 diabetes and correlated with insulin resistance
Circulating CTRP9 levels are increased in patients with newly diagnosed type 2 diabetes and correlated with insulin resistance
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新诊断 2 型糖尿病患者的循环 CTRP9 水平升高，且与胰岛素抵抗相关
DOI：
10.1016/j.diabres.2017.07.003
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发表时间：
2017-09-01
影响因子：
5.1
通讯作者：
Li, Xiaoqiang
中科院分区：
文献类型：
--
作者：
Jia, Yanjun;Luo, Xiaohe;Li, Xiaoqiang
目的：C1q/肿瘤坏死因子相关蛋白-9(CTRP9)是一种新型脂肪因子，具有促进脂代谢、增强胰岛素敏感性和预防心血管疾病等作用。然而，关于CTRP9和胰岛素抵抗之间的联系，以前在人类身上的研究得出了有争议的结果。方法：选择糖耐量正常(NGT，n=108)、糖耐量低减(IGT，n=92)和新诊断的2型糖尿病(nT2 DM，n=106)患者，采用双抗体夹心酶联免疫吸附试验检测CTRP9和脂联素水平。对所有参与者进行了与胰岛素抵抗、肥胖症和血脂谱相关的人体测量和生化测量。结果：IGT和nT2 DM患者外周血CTRP9水平均显著高于NGT患者。超重/肥胖者的CTRP9水平明显高于瘦肉者，而且在所有受试者中，女性的CTRP9水平也高于男性。此外，循环CTRP9水平与体重指数、空腹血糖、胰岛素、糖化血红蛋白、胰岛素抵抗和低密度脂蛋白胆固醇呈正相关，与高密度脂蛋白胆固醇和脂联素呈负相关。结论：CTRP9与胰岛素抵抗密切相关，提示CTRP9可能在2型糖尿病的发生发展中起重要作用。(C)2017爱思唯尔B.V.保留所有权利。
Aims: C1q/TNF-related protein-9 (CTRP9) is a novel adipokine that has been shown to promote lipid metabolism, enhance insulin sensitivity and protect against cardiovascular disease. However, previous studies in humans have produced controversial results regarding the association between CTRP9 and insulin resistance. The objective of this study was to evaluate the relationships between CTRP9 and insulin resistance in Chinese population.Methods: Subjects with normal glucose tolerance (NGT, n = 108), impaired glucose tolerance (IGT, n = 92), and newly diagnosed type 2 diabetes mellitus (nT2DM, n = 106) were recruited to determining the circulating CTRP9 and adiponectin levels by enzyme linked immunosorbent assay. Anthropometric and biochemical measurements related to insulin resistance, adiposity and lipid profile were examined for all participants. Oral glucose tolerance test was performed in healthy subjects (17 male and 17 female).Results: Circulating CTRP9 level was significantly higher in both IGTand nT2DM than in individuals with NGT. Overweight/obese subjects had much higher CTRP9 levels than lean individuals, and in all subjects, females also had higher CTRP9 levels than males. In addition, circulating CTRP9 level was positively correlated with markers of obesity and insulin resistance, including body mass index, fasting blood glucose, insulin, HbA1c, homeostasis model assessment of insulin resistance and low-density lipoprotein-cholesterol, while was inversely correlated with high-density lipoprotein-cholesterol and adiponectin. Moreover, hyperglycemia during an oral glucose challenge increased circulating CTRP9 concentrations.Conclusions: We conclude that CTRP9 was strongly associated with insulin resistance, suggesting that CTRP9 might be important in the development of type 2 diabetes. (C) 2017 Elsevier B.V. All rights reserved.