GROWTH OF SEGMENTAL NERVES FROM THE BRACHIAL MYOTOMES INTO THE PROXIMAL MUSCLES OF THE CHICK FORELIMB DURING DEVELOPMENT
GROWTH OF SEGMENTAL NERVES FROM THE BRACHIAL MYOTOMES INTO THE PROXIMAL MUSCLES OF THE CHICK FORELIMB DURING DEVELOPMENT
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DOI：
10.1002/cne.901890209
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发表时间：
1980-01-01
影响因子：
2.5
通讯作者：
UEBEL, KE
中科院分区：
文献类型：
--
作者：
BENNETT, MR;DAVEY, DF;UEBEL, KE
研究了节段神经13-16（SN 13至SN 16）从它们刚刚到达臂肌节末端（阶段21：Hamburger和汉密尔顿，1951）的时间到它们进入鸡肢芽中新形成的腹侧（阶段24）和背侧（阶段25）前肌细胞团的生长。在第22阶段，SN 13至SN 16的轴突束已经从它们各自的肌节的末端生长出来，并且在节段水平15处朝向肢芽中最密集的间充质会聚。因此，SN 14和SN 16的第一轴突束几乎已经与SN 15的轴突束连接，而进一步去除的SN 13轴突束尚未达到SN 15的水平。到第23阶段，从SN 14到SN 16的第一轴突束在节段水平15处连接以形成朝向腹侧前肌细胞团生长的神经。在第24阶段，SN 13的轴突束与SN 14至SN 16的轴突束汇合，形成臂长肌下神经，进入腹前肌的致密区。从SN 13到SN 15的其他轴突沿着由早期到达的轴突束提供的路径朝向腹侧前肌生长，但是从节段水平14处的那些轴突分叉以生长到背侧前肌。到第25阶段，SN 13至SN 15的25个轴突束已经汇合形成进入背侧前肌的致密区的臂长肌上级神经。在阶段26，由于阶段22和25之间的节段神经的这种生长模式，形成了神经丛。前肌细胞可以合成神经生长因子，其指导轴突生长到肢芽中。
The growth of segmental nerves 13-16 (SN13 to SN16) into the chick limb bud, from the time when they have just reached the ends of the brachial myotomes (stage 21:Hamburger and Hamilton, 1951), until they enter the newly formed ventral (stage 24) and dorsal (stage 25) pre-muscle cell masses in the limb bud was studied. At stage 22 axon bundles of SN13 to SN16 have grown off the ends of their respective myotomes, and converge towards the most densely packed mesenchyme in the limb bud at segmental level 15. As a consequence, the first axon bundles of SN14 and SN16 have almost joined those of SN15, whereas the further removed SN13 axon bundles have not yet reached the level of SN15. By stage 23 the first axon bundles from SN14 to SN16 have joined at segmental level 15 to form a nerve which grows toward the ventral pre-muscle cell mass. At stage 24 axon bundles from SN13 have joined those from SN14 to SN16 to form the brachialis longus inferior nerve, which enters the densest region of the ventral pre-muscle. Other axons from SN13 to SN15 grow along the pathways provided by the early arriving axon bundles towards the ventral pre-muscle, but diverge from those at segmental level 14 to grow to the dorsal pre-muscle. By stage 25 axon bundles from SN13 to SN15 have joined to form the brachialis longus superior nerve which enters the densest region of the dorsal pre-muscle. At stage 26 a plexus has formed due to this pattern of growth of the segmental nerves between stages 22 and 25. Pre-muscle cells may synthesize a nerve growth factor which directs the growth of axons into the limb bud.