Carotid body denervation in dogs: eupnea and the ventilatory response to hyperoxic hypercapnia.
Carotid body denervation in dogs: eupnea and the ventilatory response to hyperoxic hypercapnia.
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DOI：
10.1152/jappl.2001.91.1.328
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发表时间：
2001-07
影响因子：
3.3
通讯作者：
J. Rodman;A. Curran;K. Henderson;J. Dempsey;Curtis A. Smith
中科院分区：
文献类型：
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作者：
J. Rodman;A. Curran;K. Henderson;J. Dempsey;Curtis A. Smith
我们评估了清醒雌犬颈动脉PCO(2) （Pa(CO(2))）变化的时间过程和颈动脉体切除（CBX）后高氧再呼吸的通气反应。在数据收集的每一天，通过消除对静脉注射NaCN的通气反应来确认CBX状态。相对于对照组（Pa(CO(2)) = 40 +/- 3 Torr），所有7只狗在CBX后通气不足，在CBX后第3天达到最大Pa(CO(2)) 53 +/- 6 Torr。在随后的18天内，epneic Pa（CO(2)）没有明显的恢复。与对照组相比，高氧CO(2)通气（吸气分钟通气量变化/末潮PCO变化(2)）和潮气量（潮气量变化/末潮PCO变化(2)）响应斜率在cbx后第2天分别下降了40 +/- 15%和35 +/- 20%。在随后的19天里，高氧高碳酸血症的通气或潮气量反应斜率没有恢复。我们得出的结论是：1)颈动脉体贡献了大约40%的呼吸加速驱动和高氧高碳酸血症通气反应；2)去除颈动脉化学感受器后，呼吸加速驱动和高氧高碳酸血症通气反应没有恢复，表明CBX后成年犬缺乏中央或主动脉化学感受器可塑性。
We assessed the time course of changes in eupneic arterial PCO(2) (Pa(CO(2))) and the ventilatory response to hyperoxic rebreathing after removal of the carotid bodies (CBX) in awake female dogs. Elimination of the ventilatory response to bolus intravenous injections of NaCN was used to confirm CBX status on each day of data collection. Relative to eupneic control (Pa(CO(2)) = 40 +/- 3 Torr), all seven dogs hypoventilated after CBX, reaching a maximum Pa(CO(2)) of 53 +/- 6 Torr by day 3 post-CBX. There was no significant recovery of eupneic Pa(CO(2)) over the ensuing 18 days. Relative to control, the hyperoxic CO(2) ventilatory (change in inspired minute ventilation/change in end-tidal PCO(2)) and tidal volume (change in tidal volume/ change in end-tidal PCO(2)) response slopes were decreased 40 +/- 15 and 35 +/- 20% by day 2 post-CBX. There was no recovery in the ventilatory or tidal volume response slopes to hyperoxic hypercapnia over the ensuing 19 days. We conclude that 1) the carotid bodies contribute approximately 40% of the eupneic drive to breathe and the ventilatory response to hyperoxic hypercapnia and 2) there is no recovery in the eupneic drive to breathe or the ventilatory response to hyperoxic hypercapnia after removal of the carotid chemoreceptors, indicating a lack of central or aortic chemoreceptor plasticity in the adult dog after CBX.