Thermoresponsive Nanocomposite Hydrogels: Transparency, Rapid Deswelling and Cell Release.
Thermoresponsive Nanocomposite Hydrogels: Transparency, Rapid Deswelling and Cell Release.
复制标题
热响应纳米复合水凝胶：透明、快速消溶胀和细胞释放。
DOI：
10.1166/jbt.2011.1005
复制
发表时间：
2011
影响因子：
0.1
通讯作者：
Grunlan,MelissaA
中科院分区：
文献类型：
--
作者：
Hou,Yaping;Fei,Ruochong;Burkes,JonathanC;Lee,ShinDuk;Munoz-Pinto,Dany;Hahn,MariahS;Grunlan,MelissaA
Thermal modulation reversibly switches poly(N-isopropylacrylamide) (PNIPAAm) hydrogels between a water-swollen and a deswollen state which is useful for a variety of biomedical applications. The utility and efficiency of PNIPAAm hydrogels requires tailoring their rate of deswelling/reswelling, mechanical properties and/or optical clarity. In the current work, we prepared novel thermoresponsive nanocomposite hydrogels comprised of a PNIPAAm hydrogel matrix and polysiloxane colloidal nanoparticles (∼54 nm ave. diameter) via in situ photopolymerization of aqueous solutions of NIPAAm monomer, N, N′-methylenebisacrylamide (BIS, crosslinker), photoinitiator and 0.5–4.0 wt% polysiloxane nanoparticles (wt% solids of nanoparticles with respect to NIPAAm weight) at ∼7 °C. At these nanoparticle concentrations, the nanocomposite hydrogels were more optically transparent versus those prepared with analogous larger nanoparticles (∼219 nm ave. diameter). The volume phase transition temperature (VPTT) of the nanocomposite hydrogels was conveniently unaltered versus that of the pure PNIPAAm hydrogel. Incorporation of nanoparticles caused enhancement in modulus as well as the extent and rate of deswelling. When cooled from 37 °C to 25 °C, mouse smooth muscle precursor cells (10T1/2) were effectively detached from nanocomposite hydrogel surfaces due to hydrogel swelling.
登录
查看更多内容
影响因子：
2.7
作者：
Cunliffe, D;Smart, CA;Vulfson, EN
通讯作者：
Vulfson, EN
影响因子：
4.6
作者：
Harmon, ME;Tang, M;Frank, CW
通讯作者：
Frank, CW
光聚合聚(N-异丙基丙烯酰胺)薄膜的合成与表征
影响因子：
3.4
作者：
Dipti Singh;D. Kuckling;V. Choudhary;H. Adler;V. Koul
通讯作者：
V. Koul
制备温度对温敏水凝胶某些性能的影响
DOI：
10.1016/0966-7822(94)00030-b
发表时间：
1995
期刊：
Polymer Gels and Networks
影响因子：
--
作者：
C. Rathjen;Chang;P. Goodrich;D. Walgenbach
通讯作者：
D. Walgenbach
梳型接枝聚（N-异丙基丙烯酰胺）水凝胶快速收缩的微观意义
DOI：
--
发表时间：
2003
期刊：
Polymer 44
影响因子：
--
作者：
T.Sakurai;H.Miike;K.Okada;S.C.Muller;T.Matsuura et al.
通讯作者：
T.Matsuura et al.