Effect of the serotonin reuptake inhibitor fluoxetine on corticotropin-releasing factor and vasopressin secretion into hypophysial portal blood.
Effect of the serotonin reuptake inhibitor fluoxetine on corticotropin-releasing factor and vasopressin secretion into hypophysial portal blood.
复制标题
血清素再摄取抑制剂氟西汀对促肾上腺皮质激素释放因子和垂体门静脉血中加压素分泌的影响。
DOI：
10.1016/0006-8993(83)91189-7
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发表时间：
1983
期刊：
影响因子：
2.9
通讯作者：
Vale,W
中科院分区：
文献类型：
--
作者：
Gibbs,DM;Vale,W
使用5-羟色胺再摄取抑制剂氟西汀研究了促肾上腺皮质激素释放因子（CRF）和精氨酸加压素（AVP）在介导肾上腺皮质激素诱导的ACTH分泌中的相对作用。氟西汀引起外周血浆ACTH和AVP浓度显著增加，以及垂体门静脉血浆CRF和AVP浓度显著增加。这些数据表明，增加分泌的促肾上腺皮质激素诱导氟西汀介导的，至少部分是通过增加下丘脑分泌的CRF和AVP。
The relative role of corticotropin-releasing factor (CRF) and arginine vasopressin (AVP) in mediating serotonin-induced ACTH secretion was studied using the serotonin reuptake inhibitor fluoxetine. Fluoxetine caused a significant increase in ACTH and AVP concentrations in peripheral plasma as well as a significant increase in CRF and AVP concentrations in hypophysial portal plasma. The data suggest that increased secretion of ACTH induced by fluoxetine is mediated, at least in part, by an increase in the hypothalamic secretion of both CRF and AVP.