Role of cis-Monounsaturated Fatty Acids in the Prevention of Coronary Heart Disease.
Role of cis-Monounsaturated Fatty Acids in the Prevention of Coronary Heart Disease.
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DOI：
10.1007/s11883-016-0597-y
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发表时间：
2016-07
影响因子：
5.8
通讯作者：
Mensink RP
中科院分区：
文献类型：
--
作者：
Joris PJ;Mensink RP
顺式单不饱和脂肪酸(cis-MUFAs)对冠心病(CHD)风险和死亡率的影响尚不清楚。此外，不同组织得出的关于顺-多不饱和脂肪酸的饮食建议也不一致。早期的研究主要集中在顺式MUFA对血脂和脂蛋白的影响。然而，最近的研究也讨论了顺式多不饱和脂肪酸对其他非传统冠心病风险标记物的影响，如血管功能标记物、餐后血管功能以及能量摄入和代谢。尽管以CHD事件为终点的设计良好的随机对照试验还未见报道，但最近已经发表了几项关于顺式MUFA和CHD风险之间关系的大型前瞻性队列研究。本文的目的是综述近3年来发表的关于顺式-MUFA对心血管危险标记物和冠心病影响的新研究。
The effects of cis-monounsaturated fatty acids (cis-MUFAs) on the risk of coronary heart disease (CHD) and on CHD mortality are not clear. Also, dietary recommendations for cis-MUFA as derived by various organizations are not in agreement. Earlier studies have mainly focused on the effects of cis-MUFA on serum lipids and lipoproteins. More recent studies, however, have also addressed effects of cis-MUFA on other non-traditional CHD risk markers such as vascular function markers, postprandial vascular function, and energy intake and metabolism. Although well-designed randomized controlled trials with CHD events as endpoints are missing, several large prospective cohort studies have recently been published on the relationship between cis-MUFA and CHD risk. The aim of this paper is to review these new studies that have been published in the last 3 years on the effects of cis-MUFA on cardiovascular risk markers and CHD.