Low serum osteocalcin levels are correlated with left ventricular systolic dysfunction and cardiac death in Chinese men
Low serum osteocalcin levels are correlated with left ventricular systolic dysfunction and cardiac death in Chinese men
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中国男性血清骨钙素水平低与左心室收缩功能障碍和心源性死亡相关
DOI：
10.1038/s41401-018-0080-0
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发表时间：
2019-04-01
影响因子：
8.2
通讯作者：
Bao, Yu-qian
中科院分区：
文献类型：
--
作者：
Zhang, Xue-li;Shen, Yun;Bao, Yu-qian
骨钙素是新近发现的一种由成骨细胞分泌的细胞因子，具有内分泌功能，介导能量和糖脂代谢，与心血管疾病密切相关。在这项研究中，我们探讨了血清骨钙素水平在预测左心室收缩功能不全和心源性死亡中的价值。共纳入心内科258例患者。所有受试者均行二维超声心动图检查。通过电话或电子病历告知中位随访时间为4.6年的受试者的心源性死亡。采用电化学发光免疫分析法测定血清骨钙素水平。我们发现，男性左心室射血分数（LVEFs）的中位数为62%，女性为63%。在LVEF > 62%的男性中，血清骨钙素水平显著高于LVEF> 62%的男性，
Osteocalcin is a newly identified type of cytokine secreted by osteoblasts, which has an endocrine function, mediates energy and glycol-lipid metabolism, and is closely related to cardiovascular diseases. In this study, we investigated the value of serum osteocalcin levels in predicting left ventricular systolic dysfunction and cardiac death. A total of 258 patients in the Department of Cardiology were included. Two-dimensional echocardiography was performed in all the subjects. The cardiac death of subjects occurring with a median follow-up of 4.6 years was informed via phone calls or the electronic medical records. The serum osteocalcin levels were measured using electrochemiluminescent immunoassay. We found that the median left ventricular ejection fractions (LVEFs) were 62% in men and 63% in women. In the men with a LVEF > 62%, the serum osteocalcin levels were significantly higher than in those with LVEF