Synthesis and biological activity of 2-fluoro adenine and 6-methyl purine nucleoside analogs as prodrugs for suicide gene therapy of cancer.
Synthesis and biological activity of 2-fluoro adenine and 6-methyl purine nucleoside analogs as prodrugs for suicide gene therapy of cancer.
复制标题
2-氟腺嘌呤和6-甲基嘌呤核苷类似物作为癌症自杀基因治疗前药的合成和生物活性。
DOI：
10.1081/ncn-200059237
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Secrist3rd,JA
中科院分区：
文献类型：
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作者：
Silamkoti,AV;Allan,PW;Hassan,AEA;Fowler,AT;Sorscher,EJ;Parker,WB;Secrist3rd,JA
A novel series of 6-methylpurine nucleoside derivatives with substitutions at 5′-position have been synthesised. These compounds bear a 5′-heterocycle such as triazole or a imidazole with a two carbon chain, and an ether, thio ether or amine. To extend the SAR study of 2-fluoroadenine and 6-methyl purine nucleosides, their corresponding α–linker nucleosides with l-xylose and l-lyxose were also synthesized. All of these compounds have been evaluated for their substrate activity with E. coli PNP.
