Highly Enantioselective Construction of Axial Chirality by Palladium-Catalyzed Cycloisomerization of N-Alkenyl Arylethynylamides
Highly Enantioselective Construction of Axial Chirality by Palladium-Catalyzed Cycloisomerization of N-Alkenyl Arylethynylamides
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DOI：
10.1021/ol900373z
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发表时间：
2009-04-16
期刊：
影响因子：
5.2
通讯作者：
Tanaka, Ken
中科院分区：
文献类型：
--
作者：
Imase, Hidetomo;Suda, Takeshi;Tanaka, Ken
一种阳离子钯（II）/（S）-xyl-Segphos配合物催化N-烯基芳基乙炔酰胺的对映选择性环化异构化反应，以高产率和高ee值得到轴向手性4-芳基-2-吡啶酮。本催化剂代表了第一次通过过渡金属催化的环化异构化对轴向手性的对映选择性构建。
A cationic palladium(II)/(S)-xyl-Segphos complex catalyzes enantioselective cycloisomerizations of N-alkenyl arylethynylamides leading to axially chiral 4-aryl-2-pyridones in high yields with high ee values. The present catalysis represents the first enantioselective construction of axial chirality by the transition-metal-catalyzed cycloisomerization.