Rewiring of the Fruit Metabolome in Tomato Breeding
Rewiring of the Fruit Metabolome in Tomato Breeding
复制标题
番茄育种中果实代谢组的重新布线
DOI：
10.1016/j.cell.2017.12.019
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发表时间：
2018-01-11
期刊：
影响因子：
64.5
通讯作者：
Huang, Sanwen
中科院分区：
文献类型：
--
作者：
Zhu, Guangtao;Wang, Shouchuang;Huang, Sanwen
人类严重依赖数十种驯化植物物种，这些植物物种通过集约育种得到进一步改良。为了评估育种如何改变番茄果实代谢组，我们生成并分析了包含数百个番茄基因型的基因组、转录组和代谢组的数据集。综合结果说明了全球育种如何改变水果代谢含量。由于与附近基因的连锁，对与较大水果相关的基因等位基因的选择改变了代谢谱。五个主要基因座的选择减少了成熟果实中抗营养甾体配糖生物碱的积累，使果实更易于食用。粉红番茄的育种改变了 100 多种代谢物的含量。来自野生近缘种的抗性基因渗入品种中也导致了重大且意想不到的代谢变化。该研究揭示了番茄代谢育种历史的多组学观点，并提供了对代谢组辅助育种和植物生物学的见解。
Humans heavily rely on dozens of domesticated plant species that have been further improved through intensive breeding. To evaluate how breeding changed the tomato fruit metabolome, we have generated and analyzed a dataset encompassing genomes, transcriptomes, and metabolomes from hundreds of tomato genotypes. The combined results illustrate how breeding globally altered fruit metabolite content. Selection for alleles of genes associated with larger fruits altered metabolite profiles as a consequence of linkage with nearby genes. Selection of fivemajor loci reduced the accumulation of anti-nutritional steroidal glycoalkaloids in ripened fruits, rendering the fruit more edible. Breeding for pink tomatoes modified the content of over 100 metabolites. The introgression of resistance genes from wild relatives in cultivars also resulted in major and unexpected metabolic changes. The study reveals a multi-omics view of the metabolic breeding history of tomato, as well as provides insights into metabolome- assisted breeding and plant biology.