Smoking-adjusted lung cancer incidence among Asian-Americans (United States)
Smoking-adjusted lung cancer incidence among Asian-Americans (United States)
复制标题
DOI：
10.1007/s10552-005-0330-6
复制
发表时间：
2005-11-01
影响因子：
2.3
通讯作者：
Weiss, NS
中科院分区：
文献类型：
--
作者：
Epplein, M;Schwartz, SM;Weiss, NS
目的：居住在亚洲和夏威夷的中国妇女吸烟量低，但肺癌发病率高。为了进一步探讨这个问题，我们对居住在美国大陆的中国女性进行了一项肺癌研究。方法：利用NCI SEER项目的数据，我们确定了洛杉矶县、旧金山弗朗西斯科大都会区和西雅图-普吉特海湾区的居民，他们年龄在50岁或以上，在1999-2001年被诊断为肺癌或支气管癌，人种指定为非西班牙裔白色（n = 18，493）、中国人（n = 853）、菲律宾人（n = 615）或日本人（n = 282）。将每个亚洲亚组中观察到的性别特异性肺癌病例数与每个亚洲亚组的预期肺癌病例数进行比较。预期人数的计算方法是将非西班牙裔白人的年龄、性别和地理区域调整后的发病率乘以1990年每个亚裔亚组中目前吸烟者与白人的年龄和性别特异性百分比，然后乘以各自亚裔人口的规模。中国女性患肺癌的风险增加了四倍，菲律宾女性的风险增加了两倍，与基于美国非西班牙裔白人吸烟者比例相似的预期相比。中国、菲律宾和日本男性以及日本女性中的肺癌没有偏离预期风险。在中国妇女中，增加的风险主要局限于腺癌和大细胞未分化carcinoma.Conclusions：中国女性居民的美国西部大陆有一个更高的风险肺癌比预测从他们的烟草使用模式，就像他们在亚洲。
Objective: Chinese women residing in Asia and Hawaii have low consumption of tobacco but a high incidence of lung cancer. To explore this question further, we conducted a study of lung cancer among Chinese women residing in mainland US.Methods: Using data from NCI's SEER program, we identified residents of Los Angeles County, the San Francisco Metropolitan Area, and the Seattle-Puget Sound Area who were 50 years or older, diagnosed with cancer of the lung or bronchus in 1999-2001, with race specified as non-Hispanic white (n = 18,493), Chinese (n = 853), Filipino (n = 615), or Japanese (n = 282). The sex-specific observed number of lung cancer cases among each Asian sub-group was compared to the expected number of lung cancer cases for each Asian sub-group. The expected number was determined by multiplying the age-, sex-, and geographic area-adjusted incidence rates for non-Hispanic whites by the age- and sex-specific ratio of percentage of current smokers in each Asian sub-group to whites in 1990, and then by the size of the respective Asian populations.Results: Chinese women had a four-fold increased risk of lung cancer, and Filipino women a two-fold increased risk, compared to that expected based on rates in US non-Hispanic whites with a similar proportion of cigarette smokers. Lung cancer among Chinese, Filipino, and Japanese males, as well as Japanese females, did not deviate from expected risk. Among Chinese women, the increased risk was largely restricted to adenocarcinoma and large cell undifferentiated carcinoma.Conclusions: Chinese female residents of the western US mainland have a much higher risk of lung cancer than would be predicted from their tobacco use patterns, just as they do in Asia.