Nuclear receptor corepressor complexes in cancer: mechanism, function and regulation.
Nuclear receptor corepressor complexes in cancer: mechanism, function and regulation.
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发表时间：
2014-10
影响因子：
1.2
通讯作者：
Madeline Wong;Chun Guo;Jinsong Zhang
中科院分区：
文献类型：
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作者：
Madeline Wong;Chun Guo;Jinsong Zhang
核受体辅阻遏物（NCoR）和类维生素A和甲状腺激素受体的沉默介体（SMRT）作为多种转录因子的辅阻遏物起作用，所述转录因子包括核受体，如雌激素受体和雄激素受体。在许多类型的癌症和白血病中已经观察到NCoR和SMRT的失调功能。NCoR和SMRT直接与转录因子结合，并形成稳定的复合物，包括组蛋白去乙酰化酶3，转导素b样蛋白1/TBL 1相关蛋白1和G蛋白途径抑制因子2。这些NCoR/SMRT相互作用蛋白在癌症中也显示出失调的功能。在这篇综述中，我们总结了文献的机制，调节和功能的核心组件的NCoR/SMRT复合物的背景下，他们参与癌症和白血病。虽然目前的研究支持这样的观点，即辅阻遏物是癌症治疗的有前途的目标，阐明辅阻遏物参与个别类型的癌症的机制可能需要有效的治疗。
Nuclear receptor corepressor (NCoR) and silencing mediator for retinoid and thyroid hormone receptors (SMRT) function as corepressors for diverse transcription factors including nuclear receptors such as estrogen receptors and androgen receptors. Deregulated functions of NCoR and SMRT have been observed in many types of cancers and leukemias. NCoR and SMRT directly bind to transcription factors and nucleate the formation of stable complexes that include histone deacetylase 3, transducin b-like protein 1/TBL1-related protein 1, and G-protein pathway suppressor 2. These NCoR/SMRT-interacting proteins also show deregulated functions in cancers. In this review, we summarize the literature on the mechanism, regulation, and function of the core components of NCoR/SMRT complexes in the context of their involvement in cancers and leukemias. While the current studies support the view that the corepressors are promising targets for cancer treatment, elucidation of the mechanisms of corepressors involved in individual types of cancers is likely required for effective therapy.