CONCURRENT OVERPRODUCTION OF SYNAPSES IN DIVERSE REGIONS OF THE PRIMATE CEREBRAL-CORTEX
CONCURRENT OVERPRODUCTION OF SYNAPSES IN DIVERSE REGIONS OF THE PRIMATE CEREBRAL-CORTEX
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DOI：
10.1126/science.3952506
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发表时间：
1986-04-11
期刊：
影响因子：
56.9
通讯作者：
GOLDMANRAKIC, PS
中科院分区：
文献类型：
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作者：
RAKIC, P;BOURGEOIS, JP;GOLDMANRAKIC, PS
在灵长类动物大脑皮层的视觉、躯体感觉、运动和前额叶区域的不同层中，突触以相同的速度同时发育。在解剖学上和功能上不同的区域中的突触发生的这种等时过程表明，整个大脑皮层作为一个整体发育，并且在该结构中细胞与细胞通信的建立可能由单个遗传或体液信号协调。这与传统的皮层区域层次发展的观点相反，并为皮层功能的成熟提供了新的见解。
Synapses develop concurrently and at identical rates in different layers of the visual, somatosensory, motor, and prefrontal areas of the primate cerebral cortex. This isochronic course of synaptogenesis in anatomically and functionally diverse regions indicates that the entire cerebral cortex develops as a whole and that the establishment of cell-to-cell communication in this structure may be orchestrated by a single genetic or humoral signal. This is in contrast to the traditional view of hierarchical development of the cortical regions and provides new insight into the maturation of cortical functions.