KINDLING IN DEVELOPING ANIMALS - EXPRESSION OF SEVERE SEIZURES AND ENHANCED DEVELOPMENT OF BILATERAL FOCI
KINDLING IN DEVELOPING ANIMALS - EXPRESSION OF SEVERE SEIZURES AND ENHANCED DEVELOPMENT OF BILATERAL FOCI
复制标题
DOI：
10.1016/0165-3806(90)90093-e
复制
发表时间：
1990-11-01
期刊：
影响因子：
--
通讯作者：
MOSHE, SL
中科院分区：
文献类型：
--
作者：
HAAS, KZ;SPERBER, EF;MOSHE, SL
在成年大鼠中，两个边缘部位之间的交替刺激可以导致一个部位正常点燃，而另一个部位在早期非全身性点燃阶段被延迟。这种现象被称为点燃对抗。在这份报告中，我们提出的数据表明，点燃拮抗没有发生在16日龄大鼠。相反，16日龄的大鼠在杏仁核和海马区接受交替刺激后，会逐渐出现更严重的癫痫发作。与单一部位的点燃相比，交替刺激点燃两个病灶的速度要快得多，无论是在海马体还是杏仁核。所有组均出现全身性癫痫发作，包括癫痫发作阶段6和7，包括疯狂跳跃、发声和强直奔跑。与成年犬相比，幼犬在相对较少的刺激后就会出现这些癫痫发作。结果表明，未成熟的大脑抑制癫痫发作泛化的能力弱于成人。双侧病灶的年龄特异性增强可能是由于抑制系统不发达，并可能是未成熟的中枢神经系统发展为多灶性癫痫的基础。
In adult rats, alternating stimulations between two limbic sites can result in one site kindling normally, while the other is retarded in an early non-generalized kindling stage. This phenomenon has been named kindling antagonism. In this report, we present data indicating that kindling antagonism does not occur in 16-day-old rats. Instead, 16-day-old rats receiving alternating stimulations in the amygdala and hippocampus develop progressively more severe seizures. Kindling with alternate stimulations is elicited at a much faster rate at the two foci compared to kindling from a single site, either the hippocampus or amygdala. All groups develop generalized seizures including seizure stages 6 and 7, consisting of wild jumping, running with vocalizations and tonus. These seizures appear after relatively few stimulations in the pup, in comparison to the adult. The results indicate that the immature brain is less able to suppress the generalization of seizures than the adult. The age-specific enhanced development of bilateral foci may be due to underdeveloped inhibitory systems and may underlie the propensity of the immature CNS to develop multifocal seizures.