Novel Bartonella Species in Insectivorous Bats, Northern China.
Novel Bartonella Species in Insectivorous Bats, Northern China.
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中国北方食虫蝙蝠中的巴尔通体新物种
DOI：
10.1371/journal.pone.0167915
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发表时间：
2017
期刊：
影响因子：
3.7
通讯作者：
Yu XJ
中科院分区：
文献类型：
--
作者：
Han HJ;Wen HL;Zhao L;Liu JW;Luo LM;Zhou CM;Qin XR;Zhu YL;Zheng XX;Yu XJ
巴尔通体属是新兴的人类病原体。已知蝙蝠携带多种巴尔通体，其中一些能够感染人类。然而，作为第二大哺乳动物群体的一些物种，蝙蝠作为巴尔通体物种的水库的作用没有得到充分的探讨，在其物种多样性和全球分布。我国，特别是北方，有许多特有的食虫蝙蝠，但据我们所知，目前还没有关于蝙蝠巴尔通体的研究。本研究的目的是调查中国北方蝙蝠中巴尔通体的流行情况和遗传多样性。PCR扩增gltA基因，在蒙阴县107只蝙蝠中检出巴尔通体25.2%（27/107），其中铁菊头蝠1/3，微小菊头蝠2/10，流苏鼠耳蝠9/16，里氏鼠耳蝠1/5，佩氏鼠耳蝠14/58。系统发育分析表明，本研究中在蝙蝠中检测到的巴尔通体可分为10个类群，其中一些可能是新的巴尔通体。巴尔通体属物种和蝙蝠物种之间的关联被证明，并与不同的巴尔通体属物种在一个单一的蝙蝠的共同感染也被观察到。我们的研究结果扩大了我们对蝙蝠中巴尔通体遗传多样性的了解，并阐明了蝙蝠传播巴尔通体物种的生态学。
Bartonella species are emerging human pathogens. Bats are known to carry diverse Bartonella species, some of which are capable of infecting humans. However, as the second largest mammalian group by a number of species, the role of bats as the reservoirs of Bartonella species is not fully explored, in term of their species diversity and worldwide distribution. China, especially Northern China, harbors a number of endemic insectivorous bat species; however, to our knowledge, there are not yet studies about Bartonella in bats in China. The aim of the study was to investigate the prevalence and genetic diversity of Bartonella species in bats in Northern China. Bartonella species were detected by PCR amplification of gltA gene in 25.2% (27/107) bats in Mengyin County, Shandong Province of China, including 1/3 Rhinolophus ferrumequinum, 2/10 Rhinolophus pusillus, 9/16 Myotis fimbriatus, 1/5 Myotis ricketti, 14/58 Myotis pequinius. Phylogenetic analysis showed that Bartonella species detected in bats in this study clustered into ten groups, and some might be novel Bartonella species. An association between Bartonella species and bat species was demonstrated and co-infection with different Bartonella species in a single bat was also observed. Our findings expanded our knowledge on the genetic diversity of Bartonella in bats, and shed light on the ecology of bat-borne Bartonella species.