ON THE INTERPRETATION OF MULTI-HIT SURVIVAL CURVES
ON THE INTERPRETATION OF MULTI-HIT SURVIVAL CURVES
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DOI：
10.1073/pnas.35.12.696
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发表时间：
1949-01-01
影响因子：
11.1
通讯作者：
NORMAN, A
中科院分区：
文献类型：
--
作者：
ATWOOD, KC;NORMAN, A
介绍。-生存曲线占辐射对微生物影响数据的很大一部分，一般分为两类：指数型或单次撞击和s形型或多次撞击。不幸的是，在解释这些数据时，除了曲线本身的形式之外，几乎没有什么标准可用，但仅此一点就为推测生物体的某些特性提供了充分的依据。指数生存既可以解释为单次命中杀死2人，也可以解释为种群在抗辐射方面呈指数分布。有几个因素使单一
Introduction.-Survival curves, which comprise a large proportion of the data on the effects of radiation on microorganisms, generally fall into two categories: the exponential or single-hit and the sigmoid or multi-hit. It is unfortunate that in the interpretation of such data few criteria have been available other than the form of the curves themselves, but this alone has provided sufficient grounds for speculation on some properties of the organisms. Exponential survival can be explained either on the basis of a single hit to killl'2 or a population distributed exponentially with respect to resistance to radiation. 3 Several considerations which make the single-