Pulsed Transcranial Red/Near-Infrared Light Therapy Using Light-Emitting Diodes Improves Cerebral Blood Flow and Cognitive Function in Veterans with Chronic Traumatic Brain Injury: A Case Series
Pulsed Transcranial Red/Near-Infrared Light Therapy Using Light-Emitting Diodes Improves Cerebral Blood Flow and Cognitive Function in Veterans with Chronic Traumatic Brain Injury: A Case Series
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DOI：
10.1089/photob.2018.4489
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发表时间：
2019-02-01
影响因子：
1.8
通讯作者：
Hurtado, Timothy
中科院分区：
文献类型：
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作者：
Hipskind, S. Gregory;Grover, Fred L., Jr.;Hurtado, Timothy
目的：本研究探讨了使用三种不同频率的发光二极管（LED）经颅脉冲应用红光/近红外光治疗退伍军人创伤性脑损伤（TBI）的结果。背景：使用LED的光生物调节疗法（PBMT）已被证明对人类和动物模型的TBI有积极影响。材料和方法：12名被诊断患有创伤后> 18个月的慢性TBI的有症状的退伍军人使用两个氯丁橡胶治疗垫接受脉冲经颅PBMT（tPBMT），所述氯丁橡胶治疗垫包含220个红外和180个红色LED，输出功率3.3W，平均功率密度6.4mW/cm ~ 2，持续20 min，每周3次，共6周。结果指标包括标准化神经心理学测试评分以及局部脑血流（rCBF）的定性和定量单光子发射计算机断层扫描（SPECT）测量。结果：脉冲tPBMT显着改善了15个分量表中6个分量表的神经心理学评分（40.0%; p < 0.05;双尾）。SPECT分析显示12例研究参与者中有8例（66.7%）rCBF增加。定量SPECT分析显示，该研究参与者亚组的rCBF显著增加，治疗前和治疗后每立方厘米伽马射线计数之间存在显著差异[t = 3.77，df = 7，p = 0.007，95%置信区间（95，543.21 - 21，931.82）]。这是第一个研究报告定量SPECT分析的区域感兴趣的脉冲tPBMT与LED在TBI.Conclusions：脉冲tPBMT使用LED显示承诺，在改善认知功能和rCBF数年后TBI。需要进行更大规模的对照研究。
Objective: This study explored the outcome of applying red/near-infrared light therapy using light-emitting diodes (LEDs) pulsed with three different frequencies transcranially to treat traumatic brain injury (TBI) in Veterans.Background: Photobiomodulation therapy (PBMT) using LEDs has been shown to have positive effects on TBI in humans and animal models.Materials and methods: Twelve symptomatic military Veterans diagnosed with chronic TBI > 18 months posttrauma received pulsed transcranial PBMT (tPBMT) using two neoprene therapy pads containing 220 infrared and 180 red LEDs, generating a power output of 3.3Wand an average power density of 6.4 mW/cm(2) for 20 min, thrice per week over 6 weeks. Outcome measures included standardized neuropsychological test scores and qualitative and quantitative single photon emission computed tomography (SPECT) measures of regional cerebral blood flow (rCBF).Results: Pulsed tPBMT significantly improved neuropsychological scores in 6 of 15 subscales (40.0%; p < 0.05; two tailed). SPECT analysis showed increase in rCBF in 8 of 12 (66.7%) study participants. Quantitative SPECT analysis revealed a significant increase in rCBF in this subgroup of study participants and a significant difference between pre-treatment and post-treatment gamma ray counts per cubic centimeter [t = 3.77, df = 7, p = 0.007, 95% confidence interval (95,543.21-21,931.82)]. This is the first study to report quantitative SPECT analysis of rCBF in regions of interest following pulsed tPBMT with LEDs in TBI.Conclusions: Pulsed tPBMT using LEDs shows promise in improving cognitive function and rCBF several years after TBI. Larger, controlled studies are indicated.