LIPOPROTEIN-LIPASE ACTIVITY IN RAT-HEART AND ADIPOSE-TISSUE DURING ENDOTOXIC-SHOCK
LIPOPROTEIN-LIPASE ACTIVITY IN RAT-HEART AND ADIPOSE-TISSUE DURING ENDOTOXIC-SHOCK
复制标题
DOI：
10.1152/ajpheart.1980.238.3.h325
复制
发表时间：
1980-01-01
影响因子：
--
通讯作者：
SPITZER, JA
中科院分区：
文献类型：
--
作者：
BAGBY, GJ;SPITZER, JA
研究了大肠杆菌内毒素[etox]给药后心脏和脂肪组织脂蛋白脂酶（LPL）活性的变化。与注射生理盐水的对照组相比，给予etox的动物血浆甘油三酯水平升高。心脏LPL活性从对照大鼠中每小时每克湿重释放126.4 μ mol脂肪酸降低到注射etox后7小时的< 22.5 μ mol/g每小时。尽管在24小时内以产生0-100%死亡率的剂量给予etox，但无论剂量如何，心肌LPL活性均被抑制至相同程度（75-80%）。脂肪组织的反应不太明显。附睾脂肪垫LPL活性显着下降，在24小时的观察期内，在对照组和乙氧乙酸治疗的大鼠，后者组有点更沮丧7小时后治疗。内毒素休克时常观察到的高脂血症可能与LPL活性降低有关;降低的程度可能与组织有关。
Changes in heart and adipose tissue lipoprotein lipase (LPL) activity following administration of Escherichia coli endotoxin [etox] were studied. Plasma triglyceride levels were elevated in animals given etox compared to saline-injected controls. Heart LPL activity decreased from 126.4 .mu.mol fatty acid released per g wet wt per h in control rats to < 22.5 .mu.mol/g per h by 7 h following the injection of etox. Although etox was administered in doses producing 0-100% mortalities in a 24-h period, myocardial LPL activity was depressed to the same extent (75-80%) regardless of dose. The response of adipose tissue was less pronounced. Epididymal fat pad LPL activity fell significantly over the 24 h observation period in control and etox-treated rats with the latter group somewhat more depressed 7 h after treatment. Hypertriglyceridemia often observed during endotoxic shock may be related to depressed LPL activity; the degree of depression is probably tissue dependent.