Infusion of exogenous cholecystokinin-8, gastrin releasing peptide-29 and their combination reduce body weight in diet-induced obese male rats.
Infusion of exogenous cholecystokinin-8, gastrin releasing peptide-29 and their combination reduce body weight in diet-induced obese male rats.
复制标题
输注外源性胆囊收缩素-8、胃泌素释放肽-29 及其组合可减轻饮食诱导的肥胖雄性大鼠的体重。
DOI：
10.1016/j.appet.2016.12.001
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发表时间：
2017
期刊：
影响因子：
5.4
通讯作者：
Sayegh,AymanI
中科院分区：
文献类型：
--
作者：
Mhalhal,ThaerR;Washington,MarthaC;Newman,Kayla;Heath,JohnC;Sayegh,AymanI
我们假设外源性胃泌素释放肽-29 （GRP-29）和胆囊收缩素-8 （CCK-8）及其联合使用可降低体重（BW）。为了验证这一假设，在四组饮食性肥胖雄性大鼠（DIO）主动脉（靠近腹腔和颅肠系膜动脉连接处）每天输注一次生理盐水、CCK-8 （0.5 nmol/kg）、GRP-29 （0.5 nmol/kg）和CCK-8+GRP-29（各0.5 nmol/kg），共23天。我们发现CCK-8、GRP-29和CCK-8+GRP-29相对于生理盐水对照组降低了体重。综上所述，CCK-8、GRP-29及其联合使用均可降低DIO大鼠模型的体重。如果在胃肠道CCK-8的作用部位附近输注，GRP-29及其联合可能具有调节体重的作用。
We hypothesized that exogenous gastrin releasing peptide-29 (GRP-29), cholecystokinin-8 (CCK-8) and their combination reduce body weight (BW). To test this hypothesis, BW was measured in four groups of diet-induced obese (DIO) male rats infused in the aorta (close to the junctions of the celiac and cranial mesenteric arteries) with saline, CCK-8 (0.5 nmol/kg), GRP-29 (0.5 nmol/kg) and CCK-8+GRP-29 (0.5 nmol/kg each) once daily for a total of 23 days. We found that CCK-8, GRP-29 and CCK-8+GRP-29 reduce BW relative to saline control. In conclusion, CCK-8, GRP-29 and their combination reduce BW in the DIO rat model. If infused near their gastrointestinal sites of action CCK-8, GRP-29 and their combination may have a role in regulating BW.