Role of infection in chronic bronchitis.
Role of infection in chronic bronchitis.
复制标题
感染在慢性支气管炎中的作用。
DOI：
10.1164/arrd.1976.113.4.465
复制
发表时间：
1976
期刊：
影响因子：
--
通讯作者：
W. H. Stouch
中科院分区：
文献类型：
--
作者：
D. Gump;C. A. Phillips;B. Forsyth;K. Mcintosh;K. Lamborn;W. H. Stouch
本文对1968 ~ 1972年间25例慢性支气管炎患者进行了深入研究。进行了病毒、细菌学、真菌学和支原体研究，包括血清学和培养，试图确定这些药物在病情恶化中所起的作用。检测到所有与病情恶化相关的常见病毒制剂和冠状病毒组的2个成员，229E和OC43。116例急性发作中有三分之一（33.6%）可能与病毒感染或肺炎支原体（1例急性发作）有关。病毒感染也发生在缓解期，但更常与加重期相关（P < 0.001）。病毒感染和细菌感染之间没有明显的相互关系，肺炎链球菌和流感嗜血杆菌在加重患者的痰中都没有更频繁地出现。然而，痰中肺炎链球菌的数量在加重期明显高于缓解期（P=0.04），且其存在与痰脓量增加显著相关（P < 0.01）。流感嗜血杆菌的情况并非如此。氨苄西林对肺炎链球菌清痰有效，对流感嗜血杆菌清痰无效；四环素的情况正好相反。
Twenty-five patients with chronic bronchitis were studied intensively from 1968 to 1972. Viral, bacteriologic, mycologic, and mycoplasmal studies, both serologic and cultural, were carried out in an attempt to determine the role these agents play in exacerbations. All of the usual viral agents associated with exacerbations and 2 members of the coronavirus group, 229E and OC43, were detected. One third (33.6 per cent) of the 116 exacerbations observed could be related to viral infection or Mycoplasma pneumoniae (1 exacerbation). Viral infection was also noted to occur during periods of remission but was more commonly associated with periods of exacerbation(P less than 0.001). No interrelationship between viral and bacterial infection was apparent and neither Streptococcus pneumoniae nor Haemophilus influenzae was present more frequently in the sputum of patients in exacerbation. However, the number of S. pneumoniae organisms present in the sputum was significantly greater (P=0.04) during exacerbation than during remission and their presence was significatnly correlated with increases sputum purulence (P LESS THAN 0.01). This was not true of H. influenzae. Ampicillin was effective in clearing the sputum of S. pneumoniae but not of H. influenzae; the reverse was true of tetracycline.