Comparative genomic hybridization analysis of myoepithelial carcinoma of the breast
Comparative genomic hybridization analysis of myoepithelial carcinoma of the breast
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DOI：
10.1038/labinvest.3780087
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发表时间：
2000-06-01
影响因子：
5
通讯作者：
Lakhani, SR
中科院分区：
文献类型：
--
作者：
Jones, C;Foschini, MP;Lakhani, SR
虽然在乳腺中两种上皮细胞类型似乎有一种共同的干细胞，但绝大多数乳腺癌表现出管腔表型。单纯的肌上皮癌是罕见的。我们报告我们在这些肿瘤中发现的遗传改变。我们分析了10例纯肌上皮细胞癌，采用激光捕获显微切割和比较基因组杂交。平均变化数为2.1（范围0-4），而乳腺导管癌的平均变化数为8.6（范围3.6-13.8）。常见的改变包括16 q（3/10例）、17 p（3/10例）、11 q（2/10例）和16 p（2/10例）缺失，这些区域在导管癌中也常缺失。单一的情况下，其中纯肌上皮癌和浸润性导管癌都存在显示2个改变，在肌上皮肿瘤（损失在17 p和17 q），而浸润性导管组件显示15个改变（5增益和9损失），包括损失在17 p。肌上皮癌和导管癌中17 p丢失的共享与乳腺中常见的干细胞模型一致。在其他侵袭性肿瘤中相对较少的遗传改变表明，肌上皮肿瘤可能是描绘乳腺肿瘤发生中重要基因的良好模型。
Although there seems to be a common stem cell for the two epithelial cell types in the breast, the Vast majority of breast cancers exhibit a luminal phenotype. Pure myoepithelial carcinomas are rare. We report our findings of genetic alterations in these tumors. We have analyzed 10 cases of pure myoepithelial cell carcinomas using laser capture microdissection and comparative genomic hybridization. The mean number of changes was 2.1 (range 0-4), compared with a mean of 8.6 (range 3.6-13.8) in unselected ductal carcinomas. Common alterations included loss at 16q (3/10 cases), 17p(3/10), 11q (2/10), and 16p (2/10), regions also commonly deleted in ductal carcinomas. The single case in which both pure myoepithelial carcinoma and invasive ductal carcinoma was present showed 2 alterations in the myoepithelial tumor (losses at 17p and 17q), whereas the invasive ductal component showed 15 alterations (5 gains and 9 losses), including loss at 17p. The sharing of 17p loss in myoepithelial and ductal carcinoma is consistent with a common stem cell model in the breast. The relatively few genetic alterations in otherwise aggressive neoplasms suggests that myoepithelial tumors may be a good model for the delineation of genes important in breast tumorigenesis.