Dry eye reversal and corneal sensation restoration with topical naltrexone in diabetes mellitus.
Dry eye reversal and corneal sensation restoration with topical naltrexone in diabetes mellitus.
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DOI：
10.1001/archophthalmol.2009.270
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发表时间：
2009-11
影响因子：
--
通讯作者：
McLaughlin, Patricia J.
中科院分区：
文献类型：
--
作者：
Zagon, Ian S.;Klocek, Matthew S.;Sassani, Joseph W.;McLaughlin, Patricia J.
确定局部应用阿片拮抗剂纳洛酮（NTX）是否能恢复糖尿病大鼠的泪液分泌和角膜感觉。用链脲佐菌素（STZ）诱导大鼠1型糖尿病（DB）模型。泪液分泌通过Schirmer试验测量，角膜敏感性通过触觉计测量。10−5 M NTX或无菌溶剂（SV）滴眼液仅给药一次或q.i.d给药1天或5天;单滴胰岛素（1 U）仅给药一次。在注射STZ后5周开始在DB大鼠中检测到干眼和角膜不敏感。一滴NTX或Q.I.D.持续1或5天，在给药后1小时内重新建立泪液产生和角膜敏感性。干眼症的逆转持续长达2-3天，这取决于药物方案，但角膜感觉的恢复持续4 - 7天。局部应用一滴胰岛素可在1小时内恢复角膜敏感性，并持续至少2天。相比之下，与接受SV的糖尿病动物相比，一滴胰岛素眼液在1、24或48小时没有增加泪液产生。NTX局部治疗可使1型糖尿病大鼠泪液生成和角膜敏感性正常化。眼表局部应用NTX可作为治疗糖尿病干眼和角膜麻醉的重要策略。应研究其在其他形式的角膜敏感性降低和/或干眼症中的影响（如果有）。
To determine if topical application of naltrexone (NTX), an opioid antagonist, restores tear production and corneal sensation in rats with diabetes. Type 1 diabetes (DB) was induced with streptozotocin (STZ) in rats. Tear production was measured by the Schirmer's test, and corneal sensitivity by an aesthesiometer. Eye drops of 10−5 M NTX or sterile vehicle (SV) were administered either once only or q.i.d for 1 or 5 days; a single drop of insulin (1 U) was given once only. Dry eye and corneal insensitivity were detected in the DB rats beginning 5 weeks after STZ injection. One drop of NTX or q.i.d. for 1 or 5 days re-established tear production and corneal sensitivity within 1 hour of administration. The reversal of dry eye lasted for up to 2–3 days depending on drug regimen, but restitution of corneal sensation lasted for 4 to 7 days. Topical application of one eye drop of insulin restored corneal sensitivity within 1 hour and lasted for at least 2 days. In contrast, one eye drop of insulin did not increase tear production at 1, 24, or 48 hours compared to diabetic animals receiving SV. Topical treatment with NTX normalizes tear production and corneal sensitivity in type 1 diabetic rats. Topical application of NTX to the ocular surface may serve as an important strategy for treating dry eye and corneal anesthesia in diabetes. Its effect, if any, in other forms of decreased corneal sensitivity and/or dry eye should be investigated.
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影响因子：
4.2
作者：
JONES, LT
通讯作者：
JONES, LT
影响因子：
--
作者：
Brown, Melissa M.;Brown, Gary C.;Roth, Zachary
通讯作者：
Roth, Zachary
影响因子：
1.7
作者：
Akinci, A.;Cetinkaya, E.;Aycan, Z.
通讯作者：
Aycan, Z.
影响因子：
4.4
作者：
Song, XJ;Li, DQ;Pflugfelder, SC
通讯作者：
Pflugfelder, SC
DOI：
10.1016/j.optm.2006.08.002
发表时间：
2006-11-01
期刊：
Optometry (St. Louis, Mo.)
影响因子：
--
作者：
Hom, Milton;De Land, Paul
通讯作者：
De Land, Paul