Estimating child mortality associated with maternal mortality from breast and cervical cancer
Estimating child mortality associated with maternal mortality from breast and cervical cancer
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DOI：
10.1002/cncr.31780
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发表时间：
2019-01-01
期刊：
影响因子：
6.2
通讯作者：
Formenti, Silvia C.
中科院分区：
文献类型：
--
作者：
Vega, Raymond B. Mailhot;Balogun, Onyinye D.;Formenti, Silvia C.
背景大规模人口研究表明，低收入和高收入国家的母亲死亡和儿童死亡率之间存在关联。作者估计了儿童死亡与母亲死于乳腺癌或宫颈癌的相关性，以对这些癌症的死亡负担进行全面评估。乳腺癌或宫颈癌是低收入和中等收入国家中影响育龄妇女的两种常见癌症。方法 设计了蒙特卡罗模拟模型，根据该模型，女性有死于乳腺癌、宫颈癌或其他原因的风险。与母亲健在的孩子相比，10 岁之前死亡的女性的孩子因各种原因死亡的风险更高。因此，进行了模拟，并量化了孟加拉国、布基纳法索和丹麦母亲死于宫颈癌和乳腺癌对相关儿童死亡率的影响（基准分析），然后将分析扩展到所有非洲国家。结果 与母亲死于乳腺癌和宫颈癌相关的儿童死亡基准估计导致孟加拉国癌症相关死亡率增加约 2%，布基纳法索增加 14%，丹麦增加不到 1%。该模型预测，在某些非洲国家，如果考虑到儿童死亡估计，综合癌症死亡人数将增加高达 30%。结论 据作者所知，这是第一项评估母亲死于癌症对儿童死亡率影响的研究。该模型的估计要求进一步调查这种相关性，并强调育龄妇女充分获得预防和治疗的相关性。 (c) 2018 年美国癌症协会。
Background Large-scale population studies demonstrate an association between mothers' deaths and child mortality in both lower and higher income countries. The authors estimated children's deaths in association with mothers' deaths from breast or cervical cancer, 2 common cancers in low-income and middle-income countries affecting women of reproductive age, to develop a comprehensive assessment of the death burden of these cancers. Methods A Monte Carlo simulation model was devised whereby women were at risk of dying from breast cancer, cervical cancer, or another cause. Compared with children who have living mothers, children of women who die before they reached age 10 years have an elevated risk of death from all causes. Therefore, simulations were conducted, and the impact of mothers' deaths from cervical and breast cancer on associated child mortality was quantified for Bangladesh, Burkina Faso, and Denmark (benchmark analysis), then the analyses were extended to all African countries. Results Benchmark estimates of child deaths associated with mothers' deaths from breast and cervical cancer resulted in an increment in cancer-related mortality of approximately 2% in Bangladesh, 14% in Burkina Faso, and less than 1% in Denmark. The model predicted an increment in comprehensive cancer deaths when including child death estimates by as high as 30% in certain African countries. Conclusions To the authors' knowledge, this is the first study to estimate the impact of a mother's death from cancer on child mortality. The model's estimates call for further investigation into this correlation and underscore the relevance of adequate access to prevention and treatment among women of childbearing age. (c) 2018 American Cancer Society.