Implications of the hyperinsulinaemia-diabetes-cancer link for preventive efforts.
Implications of the hyperinsulinaemia-diabetes-cancer link for preventive efforts.
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高胰岛素血症-糖尿病-癌症之间的联系对预防工作的影响。
DOI：
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发表时间：
1998
影响因子：
2.4
通讯作者：
H. Tsuda
中科院分区：
文献类型：
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作者：
M. Moore;C. B. Park;H. Tsuda
最近的流行病学证据表明，非胰岛素依赖型糖尿病（NIDDM）与结肠癌、肝癌、胰腺癌、乳腺癌和子宫内膜癌之间存在联系。这似乎是由于在NIDDM临床阶段之前的长时间高胰岛素血症，胰岛素促进结肠肿瘤的发展以及作为一种肝癌原。事实上，这种激素可能在肿瘤形成中起着核心作用，它的影响可以解释肥胖和高脂肪饮食的增强效应，以及与体育锻炼、脱氢表雄酮管理和高可溶性纤维摄入相关的抑制作用。因此，降低胰岛素水平的措施，包括改善生活方式和补充已知的降低胰岛素抵抗的药物，可能为预防具有重要临床意义的各种器官部位的癌症提供一种通用方法。
Recent epidemiological evidence points to a link between non-insulin dependent diabetes mellitus type II (NIDDM) and cancer of the colon, liver, pancreas, breast and endometrium. This appears to be due to the long period of hyperinsulinaemia which precedes the clinical phase of NIDDM, insulin promoting colon tumour development as well as acting as a hepatocarcinogen. Indeed, the hormone could play a central role in neoplasia, and its influence could explain the observed enhancing effects of obesity and a high fat diet, as well as the inhibition associated with physical exercise, dehydroepiandrosterone administration and high soluble fibre intake. Measures to decrease insulin levels, including lifestyle improvement and supplementation with agents known to decrease insulin resistance may therefore offer a general approach to prevention of cancer in a wide variety of organ sites of major clinical importance.