Myocyte cellular hypertrophy is responsible for ventricular remodelling in the hypertrophied heart of middle aged individuals in the absence of cardiac failure.
Myocyte cellular hypertrophy is responsible for ventricular remodelling in the hypertrophied heart of middle aged individuals in the absence of cardiac failure.
复制标题
在没有心力衰竭的情况下，肌细胞肥大是中年个体肥大心脏中心室重塑的原因。
DOI：
10.1093/cvr/28.8.1199
复制
发表时间：
1994
影响因子：
10.8
通讯作者：
Anversa,P
中科院分区：
文献类型：
--
作者：
Olivetti,G;Melissari,M;Balbi,T;Quaini,F;Cigola,E;Sonnenblick,EH;Anversa,P
目的：其目的是测量的数量和大小的变化，在人的心脏明显的心室肥大，没有明确的迹象，心力衰竭，以确定是否心肌细胞肥大是唯一的因素参与的增加，在心脏mass.Methods：形态计量技术应用于估计的数量，每单位体积的心肌细胞核，结合测定的体积百分比的心肌细胞，允许计算的平均心肌细胞体积每核和心肌细胞核的总数在心室。随后，在组织中的替代纤维化的体积分数进行了评估，并在ventricles.Results的绝对组成部分体积：八个肥厚的人的心脏，重量561（SD 68）克，在尸检时收集高血压患者死于非心脏原因，并与八个正常的心脏，重量387（37）克，从健康的人谁也死于非心脏原因进行了比较。随着心肌肥厚，左心室和右心室重量分别增加了53%和57%，而心肌细胞体积分别增加了112%和84%。心室重量增加和心肌细胞体积增加之间的不成比例是由于高血压肥大后左心室和右心室心肌细胞分别损失30%和16%。心肌细胞损失也引起了319%和188%的左心室和右心室心肌替代纤维化的数量增加。这些组织和细胞的过程导致了在心室质量超过了增厚的壁，使腔容积的增加发生在both ventriculoids.Conclusions：心肌细胞肥大是负责高血压心肌病在其补偿阶段的心室肥大的扩张。心肌细胞损失先于心室泵功能受损，可能与心室适应不良的发生有关。心血管研究1994;28：1199-1208
Objective:The aim was to measure changes in the numbers and size of ventricular myocytes in human hearts with marked ventricular hypertrophy and no clear signs of cardiac failure, to determine whether myocyte cellular hypertrophy is the only factor involved in the increase in cardiac mass.Methods:Morphometric techniques were applied to estimate the number of myocyte nuclei per unit volume of myocardium which, in combination with the determination of the volume percent of myocytes, allowed the computation of the average myocyte cell volume per nucleus and total number of myocyte nuclei in the ventricles. Subsequently, the volume fraction of replacement fibrosis in the tissue was assessed and absolute component volumes in the ventricles obtained.Results:Eight hypertrophied human hearts, weight 561(SD 68) g, were collected at necropsy from hypertensive patients who died from non-cardiac causes and were compared with eight normal hearts, weight 387(37) g, obtained from healthy individuals who also died from non-cardiac causes. With cardiac hypertrophy, left and right ventricular weight increased by 53% and 57%, whereas myocyte cell volume increased by 112% and 84%, respectively. The disproportion between the increase in ventricular weight and the increase in myocyte volume was due to a 30% and 16% loss in left and right ventricular myocytes following hypertensive hypertrophy. Myocyte loss also provoked a 319% and a 188% increase in the amount of replacement fibrosis in the left and right ventricular myocardium. These tissue and cellular processes resulted in an expansion in ventricular mass which exceeded the thickening of the wall so that an increase in cavitary volume occurred in both ventricles.Conclusions:Myocyte cellular hypertrophy is responsible for ventricular hypertrophy in hypertensive cardiomyopathy in its compensated stage. Myocyte loss precedes the impairment in ventricular pump function and may be implicated in the initiation of ventricular maladaptation.Cardiovascular Research1994;28:1199-1208