The effects of a sedative antihistamine, d-chlorpheniramine, on visuomotor spatial discrimination and regional brain activity as measured by positron emission tomography (PET)
The effects of a sedative antihistamine, d-chlorpheniramine, on visuomotor spatial discrimination and regional brain activity as measured by positron emission tomography (PET)
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DOI：
10.1002/hup.430
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发表时间：
2002-12-01
影响因子：
1.7
通讯作者：
Yanai, K
中科院分区：
文献类型：
--
作者：
Mochizuki, H;Tashiro, M;Yanai, K
虽然大多数服用抗组胺药的人都经历过镇静和行为受损，但这些镇静特性的神经相关性在人类中还没有得到很好的理解。脑成像可以用来证明在这种镇静作用期间局部脑活动是如何改变的。本研究的目的是可视化视觉空间认知受损的脑机制，口服d-氯苯那敏，第一代镇静抗组胺药，使用（H2O）-O-15和正电子发射断层扫描（PET）。正常受试者被随机分配到两组（扑尔敏和安慰剂），并进行了空间辨别任务后，口服6毫克的d-扑尔敏或安慰剂。d-扑尔敏的管理损害视觉空间的歧视和改变皮层和皮层下的活动。在与视觉空间认知有关的右顶叶皮层（BA 40）和构成大脑注意系统的后扣带皮层中分别观察到活动减少和增加。特别是，BA 40的脑活动分别与双侧尾状核和背外侧前额叶皮层的脑活动呈负相关和正相关。这些研究结果清楚地表明，在皮质和皮质下活动的改变有助于受损的空间认知所造成的治疗与d-扑尔敏。版权所有（C）2002约翰威利父子有限公司
Although most people taking antihistamines have experienced sedation and impaired performance, the neural correlates of these sedative properties are not well understood in man. Brain imaging can be used to demonstrate how regional brain activities are altered during such sedative effects. The aim of this study was to visualize the brain mechanism of impaired visuomotor spatial cognition with orally administered d-chlorpheniramine, a first-generation sedative antihistamine, using (H2O)-O-15 and positron emission tomography (PET). Normal subjects were randomly assigned to two groups (chlorpheniramine and placebo) and performed a spatial discrimination task after the oral administration of 6 mg d-chlorpheniramine or a placebo. The administration of d-chlorpheniramine impaired visuomotor spatial discrimination and altered cortical and subcortical activity. Decreased and increased activities were observed in the right parietal cortex (BA 40) which is related to visuomotor spatial cognition and the posterior cingulate cortex which constitutes the attention system of the brain, respectively. In particular, the brain activities of BA 40 were negatively and positively correlated to those of bilateral caudate nuclei and the dorsolateral prefrontal cortex, respectively. These findings clearly suggest that the alteration in the cortical and subcortical activity contributes to impaired spatial cognition caused by treatment with d-chlorpheniramine. Copyright (C) 2002 John Wiley Sons, Ltd.