Eosinophil-derived transforming growth factors (TGF-alpha and TGF-beta 1) in human periradicular lesions.
Eosinophil-derived transforming growth factors (TGF-alpha and TGF-beta 1) in human periradicular lesions.
复制标题
人根周病变中嗜酸性粒细胞衍生的转化生长因子（TGF-α 和 TGF-β 1）。
DOI：
10.1016/s0099-2399(99)80322-7
复制
发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Wong,DT
中科院分区：
文献类型：
--
作者：
Tyler,LW;Matossian,K;Todd,R;Gallagher,GT;White,RR;Wong,DT
神经根周围病变的炎症介质了解甚少。转化生长因子-α和-β1（TGF-α和TGF-β1）与软硬组织伤口愈合的细胞过程有关。本研究的目的是通过原位杂交和免疫组织化学的方法来证实TGF-α和TGF-β1mRNA和蛋白在根尖周围病变中的细胞来源。检查了9例根尖周围肉芽肿和9例根尖周围囊肿。在肉芽肿中未检测到TGF-α mRNA和蛋白。然而，尖周囊肿周围的嗜酸性粒细胞显示TGF-α mRNA和蛋白。绝大多数存在于根尖周围肉芽肿和囊肿中的嗜酸性粒细胞也表达TGF-β1mRNA和蛋白。其他产生TGF-β1的细胞有淋巴细胞、成纤维细胞和单核细胞。创面修复细胞因子TGF-α和TGF-β1的存在提示宿主炎症反应参与根尖周围组织修复和重塑的机制。
Inflammatory mediators of periradicular lesions are poorly understood. Transforming growth factors-α and -β1(TGF-α and TGF-β1) have been linked with the cellular processes for both soft and hard tissue wound healing. The purpose of this study is to demonstrate the cellular sources of TGF-α and TGF-β1mRNA and protein in periapical lesions by in situ hybridization and immunohistochemistry. Nine periapical granulomas and nine periapical cysts were examined. TGF-α mRNA and protein were not detectable in the granulomas examined. However, eosinophils surrounding the periapical cysts demonstrated both TGF-α mRNA and protein. The vast majority of eosinophils present in the periapical granulomas and cysts also demonstrated TGF-β1mRNA and protein. Other cells producing TGF-β1were lymphocytes, fibroblasts, and monocytes. The presence of wound repair cytokines, such as TGF-α and TGF-β1, suggests a mechanism by which the host inflammatory response may participate in the repair and remodeling of periapical tissues.