Polypoidal Choroidal Vasculopathy.
Polypoidal Choroidal Vasculopathy.
复制标题
DOI：
10.1007/s40135-017-0137-0
复制
发表时间：
2017-06
影响因子：
0.9
通讯作者：
Kuriyan AE
中科院分区：
文献类型：
--
作者：
Kim JB;Nirwan RS;Kuriyan AE
本文的目的是回顾息肉状脉络膜血管病变（PCV）的最新文献，并提供流行病学、病理生理学、临床表现和治疗的最新信息。尽管吲哚菁绿血管造影（ICGA）仍然是诊断PCV的金标准，但使用enface光学相干断层扫描（OCT）和OCT血管造影是诊断PCV的有用工具。研究表明，光动力疗法 (PDT) 和抗血管内皮生长因子 (VEGF) 联合疗法具有优异的治疗效果。 PCV 是一种最常见于亚洲人和非裔美国人的疾病，表现为黄斑或视乳头周围区域出现橙红色结节。虽然 ICGA 仍然是诊断 PCV 的最准确方法，但更新的非侵入性成像方式（例如 OCT-A 和正面 OCT）可用于识别 PCV 病变。 PDT 和抗 VEGF 疗法的组合优于任一单一疗法。 OCT 模式和其他抗 VEGF 药物的未来研究将分别对指导 PCV 诊断和治疗具有重要意义。
The goal of this paper is to review the recent literature of polypoidal choroidal vasculopathy (PCV) and provide an update on the epidemiology, pathophysiology, clinical findings, and management. Although indocyanine-green angiography (ICGA) is still the gold standard for diagnosis of PCV, the use of en face optical coherence tomography (OCT) and OCT angiography are useful tools in the diagnosis of PCV. Studies demonstrate superior treatment outcomes with combination photodynamic therapy (PDT) and anti-vascular endothelial growth factor (VEGF) therapy. PCV is a disease most commonly in Asians and African-Americans and presents with an orange-red nodule in the macula or the peripapillary region. While ICGA remains the most accurate method to diagnose PCV, newer non-invasive imaging modalities (eg. OCT-A and en face OCT) can be used to identify PCV lesions. The combination of PDT and anti-VEGF therapy is superior to either monotherapy. Future studies of OCT modalities and other anti-VEGF agents will be important in guiding PCV diagnosis and management, respectively.