More than a flying syringe: Using functional traits in vector-borne disease research
More than a flying syringe: Using functional traits in vector-borne disease research
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不仅仅是飞行注射器：在媒介传播疾病研究中利用功能特征
DOI：
10.1101/501320
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Cator L
中科院分区：
文献类型：
--
作者：
Cator L
媒介生物是许多重要的地方性和新出现疾病传播的罪魁祸首。这些动物的功能特征不仅对病原体传播有重要影响，而且对病媒本身的适合性和种群动态也有重要影响。越来越多的经验证据表明，媒介特性在与传播动力学相关的时间尺度上存在显著差异。目前，由于缺乏经验数据以及将特征机械地纳入传播模型的理论方法，人们无法理解关键性状的这种变异如何影响传播。在这里，我们提出了一个框架，将媒介性状的内在和环境驱动的变异纳入到经验性和理论性的媒介传播疾病研究中。这个框架机械地捕捉了特征变异对媒介适合度的影响，媒介特征之间的相关性，以及这些因素如何共同决定传播动力学。我们说明了基于特征的病媒传播疾病模型如何做出新的预测，并确定了在此类模型的构建、经验参数化和验证中的关键步骤和挑战。或许最重要的是，这一框架还可用于确定数据收集工作的优先顺序。
Vectors are responsible for the transmission of many important endemic and emerging diseases. The functional traits of these animals have important consequences for pathogen transmission, but also for fitness and population dynamics of the vectors themselves. Increasing empirical evidence suggests that vector traits vary significantly at time scales relevant to transmission dynamics. Currently, an understanding of how this variation in key traits impacts transmission is hindered by a lack of empirical data as well theoretical methods as for mechanistically incorporating traits into transmission models. Here, we present a framework for incorporating both intrinsic and environment-driven variation in vector traits into empirical and theoretical vector-borne disease research. This framework mechanistically captures the effect of trait variation on vector fitness, the correlation between vector traits, and how these together determine transmission dynamics. We illustrate how trait-based vector-borne disease modelling can make novel predictions, and identify key steps and challenges in the construction, empirical parameterization and validation of such models. Perhaps most importantly, this framework can also be used to prioritize data collection efforts.