Patterns of glucose use after bicuculline-induced convulsions in relationship to gamma-aminobutyric acid and mu-opioid receptors in the ventral pallidum--functional markers for the ventral pallidum.
Patterns of glucose use after bicuculline-induced convulsions in relationship to gamma-aminobutyric acid and mu-opioid receptors in the ventral pallidum--functional markers for the ventral pallidum.
复制标题
荷包牡丹碱诱发惊厥后的葡萄糖使用模式与腹侧苍白球中的 γ-氨基丁酸和 mu-阿片受体（腹侧苍白球的功能标记）有关。
DOI：
10.1016/0006-8993(92)90341-6
复制
发表时间：
1992
期刊：
影响因子：
2.9
通讯作者：
Kalivas,PW
中科院分区：
文献类型：
--
作者：
Churchill,L;Cross,RS;Pazdernik,TL;Nelson,SR;Zahm,DS;Heimer,L;Kalivas,PW
荷包牡丹碱诱导的惊厥增加了整个大脑的葡萄糖使用，并明显区分了腹侧苍白球和苍白球。在荷包牡丹碱诱导的惊厥后，除了背内侧壳的一个限定区域外，丘脑核中的葡萄糖使用也增加。由于从丘脑腹侧苍白球核到腹侧苍白球的投射含有γ-氨基丁酸（GABA）和阿片肽脑啡肽，因此将荷包牡丹碱诱导惊厥后腹侧苍白球核和丘脑腹侧苍白球核中葡萄糖使用增加的模式与GABA A和μ-阿片受体的地形图进行比较。延髓核和腹侧苍白球的葡萄糖利用模式类似于GABAA的拓扑结构，但不同于μ-阿片受体。荷包牡丹碱可以解除GABA能传入腹侧苍白球的抑制，导致纹状体苍白球突触终末以及苍白球投射神经元的局部终末内葡萄糖使用的急剧增加。
Bicuculline-induced convulsions increased glucose use throughout the brain and sharply demarcated the ventral pallidum and globus pallidus. Glucose use in the nucleus accumbens also increased after bicuculline-induced convulsions, except for a circumscribed region in the dorsomedial shell. Since the projection from the nucleus accumbens to the ventral pallidum contains γ-aminobutyric acid (GABA) and the opioid peptide, enkephalin, the pattern of increased glucose use in the ventral pallidum and nucleus accumbens after bicuculline-induced convulsions was compared to the topography of GABAAand μ-opioid receptors. The pattern of glucose use in the nucleus accumbens and ventral pallidum resembled the topography of GABAA, but differed from that of μ-opioid receptors. Bicuculline may disinhibit GABAergic efferents to the ventral pallidum resulting in a dramatic increase in glucose use within striatopallidal synaptic terminals as well as in local terminals of the pallidal projection neurons.