Lipids and risk of coronary heart disease. The Framingham Study.
Lipids and risk of coronary heart disease. The Framingham Study.
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DOI：
10.1016/1047-2797(92)90033-m
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发表时间：
1992-01-01
影响因子：
5.6
通讯作者：
Levy, D
中科院分区：
文献类型：
--
作者：
Castelli, W P;Anderson, K;Levy, D
在50至79岁的女性和50至64岁的男性中，调整其他危险因素后，总胆固醇水平与冠心病（CHD）风险显着相关，P <0.001。测定脂蛋白水平，如低密度脂蛋白（LDL）胆固醇和高密度脂蛋白（HDL）胆固醇，可以提高风险的预测。甘油三酯在所有年龄段的女性中独立相关，但在男性多变量研究中缺乏统计学意义。总胆固醇-HDL胆固醇比率是所有年龄段女性的另一个强有力的预测因子，也是65至80岁男性中唯一与CHD独立相关的血脂预测因子。对胆固醇与男性和女性风险的年龄特异性关联的检查也表明，疾病的绝对比率随着年龄的增长而恶化。
Total cholesterol level is significantly related to risk of coronary heart disease (CHD), adjusting for other risk factors in women 50 to 79 years old and in men aged 50 to 64 years, at P < .001. Determining the levels of lipoproteins such as low-density-lipoprotein (LDL) cholesterol and high-density-lipoprotein (HDL) cholesterol improves the prediction of risk. Triglycerides are independently related in women at all ages but miss statistical significance in the multivariate studies in men. The total cholesterol-HDL cholesterol ratio is another powerful predictor at all ages in women and is the only lipid predictor independently related to CHD in men 65 to 80 years old. Inspection of the age-specific association of cholesterol with risk in men and women also reveals that the absolute rates of disease worsen with age.