PREVALENCE OF INFECTION WITH JUNIN VIRUS IN RODENT POPULATIONS IN THE EPIDEMIC AREA OF ARGENTINE HEMORRHAGIC-FEVER
PREVALENCE OF INFECTION WITH JUNIN VIRUS IN RODENT POPULATIONS IN THE EPIDEMIC AREA OF ARGENTINE HEMORRHAGIC-FEVER
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DOI：
10.4269/ajtmh.1994.51.554
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发表时间：
1994-11-01
影响因子：
3.3
通讯作者：
JAHRLING, PB
中科院分区：
文献类型：
--
作者：
MILLS, JN;ELLIS, BA;JAHRLING, PB
本文报道了阿根廷出血热疫区两个标记-再捕获网捕获的1101份小兽类血清中Junin病毒抗体的间接荧光抗体筛选结果。29只血清阳性动物中有26只为啮齿动物，30个月患病率为7.9%。将这些数据与先前公布的抗原检测数据相结合，估计主要宿主种的总感染率为10.9%。其他受感染的物种包括两种蟋蟀，C. laucha和Bolomys obscurus，以及一种掠食性食肉动物Galictis cuja。大约一半的受感染动物在血液和唾液中同时携带血清抗体和抗原，有些持续29-61天。除与作物生境相关的laucha外，血清阳性动物与相对罕见的路边和围栏生境密切相关。血清阳性的肌肉棘球蚴在年龄最大和体重最重的年龄组中以男性为主，血清阳性的男性出现身体疤痕的可能性是血清阴性男性的两倍。这些观察结果表明，大多数感染是通过水平传播获得的，在相对密集的路边和围栏生境中，成年雄性肌肉库蚊之间的攻击性接触是Junin病毒在水库种群中传播的重要机制。
We report the results of indirect fluorescent antibody screening for antibody to Junin virus in 1,101 sera from small mammals captured on two mark-recapture grids in the epidemic area of Argentine hemorrhagic fever. Twenty-six of 29 seropositive animals were the cricetid rodent Calomys musculinus, for a 30-month prevalence of 7.9% in that species. Combining these data with previously published data on antigen detection provided an estimated total prevalence of infection of 10.9% for this, the principal reservoir species. Other infected species included two cricetids, C. laucha and Bolomys obscurus, and a predatory carnivore, Galictis cuja. Approximately half of infected animals simultaneously carried serum antibody and antigen in blood and saliva, some for 29-61 days. Except for C. laucha, which was associated with crop habitats, seropositive animals were strongly associated with the relatively rare roadside and fence-line habitats. Seropositive C. musculinus were predominantly males in the oldest age and heaviest body mass classes, and seropositive males were twice as likely to have body scars as seronegative males. These observations suggest that most infections were acquired through horizontal transmission and that aggressive encounters among adult, male C. musculinus in relatively densely populated roadside and fence-line habitats are an important mechanism of transmission of Junin virus within reservoir populations.