Arterial pulse wave velocity in relation to carotid intima-media thickness, brachial flow-mediated dilation and carotid artery distensibility: The Cardiovascular Risk in Young Finns Study and the Health 2000 Survey
Arterial pulse wave velocity in relation to carotid intima-media thickness, brachial flow-mediated dilation and carotid artery distensibility: The Cardiovascular Risk in Young Finns Study and the Health 2000 Survey
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DOI：
10.1016/j.atherosclerosis.2011.08.007
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发表时间：
2012-02-01
期刊：
影响因子：
5.3
通讯作者：
Kahonen, Mika
中科院分区：
文献类型：
--
作者：
Koivistoinen, Teemu;Virtanen, Marko;Kahonen, Mika
目的：动脉脉搏波速度（PWV）增加是心血管事件和死亡率的强预测因子。关于PWV和其他血管损伤指标之间关系的数据有限，部分存在争议。我们进行了目前的研究，以检查PWV与早期动脉粥样硬化的非侵入性措施的关系（肱动脉血流介导的扩张[FMD]、颈动脉内膜中层厚度[IMT]）和局部动脉僵硬度（颈动脉扩张性[Cdist]）。研究人群由1754名年轻人组成这项研究是对参加芬兰青年心血管风险研究（YFS）的336名老年人（30-45岁，45.5%为男性）和参加2000年健康调查的336名老年人（46-76岁，43.2%为男性）进行的。仅在YFS队列中测量FMD。结果：在年轻人中，FMD和IMT与PWV无关，独立于心血管危险因素。此外，没有发现FMD状态调节心血管危险因素和PWV之间的关联。在老年人中，PWV和IMT直接且独立相关（β =1.233，p=0.019）。在两个队列中，PWV与Cdist呈负相关，并且这种关系仍然显著（p
Objective: Increased arterial pulse wave velocity (PWV) is a strong predictor of cardiovascular events and mortality. The data regarding the relationships between PWV and other indices of vascular damage is limited and partly controversial. We conducted the present study to examine PWV in relation to non-invasive measures of early atherosclerosis (brachial flow-mediated dilation [FMD], carotid intima-media thickness [IMT]) and local arterial stiffness (carotid artery distensibility [Cdist]).Methods: The study population consisted of 1754 young adults (aged 30-45 years, 45.5% males) participating in the Cardiovascular Risk in Young Finns Study (YFS), and of 336 older adults (aged 46-76 years, 43.2% males) participating in the Health 2000 Survey. FMD was measured only in the YFS cohort. FMD, IMT and Cdist were assessed by ultrasound, and PWV was measured using the whole-body impedance cardiography device.Results: In young adults, FMD and IMT were not associated with PWV independently of cardiovascular risk factors. Moreover, FMD status was not found to modulate the association between cardiovascular risk factors and PWV. In older adults, PWV and IMT were directly and independently associated (beta=1.233, p=0.019). In both cohorts, PWV was inversely related with Cdist, and this relation remained significant (p