The Arabidopsis thaliana Med25 mediator subunit integrates environmental cues to control plant development
The Arabidopsis thaliana Med25 mediator subunit integrates environmental cues to control plant development
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DOI：
10.1073/pnas.1002981108
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发表时间：
2011-05-17
影响因子：
11.1
通讯作者：
Bjorklund, Stefan
中科院分区：
文献类型：
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作者：
Elfving, Nils;Davoine, Celine;Bjorklund, Stefan
植物的发育受非生物环境因素如日照长度、光质、温度、干旱和盐度的控制。这些信号被多种系统感知，并通过不同的信号转导途径传递。最终，这些途径被整合以控制特定靶基因的表达，这些靶基因编码调节发育和分化的蛋白质。这种整合的分子机制仍然难以捉摸。我们在这里表明，线性的130个氨基酸长的序列中的Med25亚基的拟南芥调解人是一个共同的目标，干旱反应元件结合蛋白2A，锌指同源结构域1，和Myb样转录因子参与不同的胁迫反应途径。此外，我们的研究结果表明，Med25与干旱响应元件结合蛋白2A一起也在抑制PhyB介导的光信号传导中起作用，从而整合来自不同调控途径的信号。
Development in plants is controlled by abiotic environmental cues such as day length, light quality, temperature, drought, and salinity. These signals are sensed by a variety of systems and transmitted by different signal transduction pathways. Ultimately, these pathways are integrated to control expression of specific target genes, which encode proteins that regulate development and differentiation. The molecular mechanisms for such integration have remained elusive. We here show that a linear 130-amino-acids-long sequence in the Med25 subunit of the Arabidopsis thaliana Mediator is a common target for the drought response element binding protein 2A, zinc finger homeodomain 1, and Myb-like transcription factors which are involved in different stress response pathways. In addition, our results show that Med25 together with drought response element binding protein 2A also function in repression of PhyB-mediated light signaling and thus integrate signals from different regulatory pathways.